PDB Information

PDB6CHW
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ER alphaWTand ER alphaMUTBreast Cancer.
Puyang, X., Furman, C., Zheng, G.Z., Wu, Z.J., Banka, D., Aithal, K., Agoulnik, S., Bolduc, D.M., Buonamici, S., Caleb, B., Das, S., Eckley, S., Fekkes, P., Hao, M.H., Hart, A., Houtman, R., Irwin, S., Joshi, J.J., Karr, C., Kim, A., Kumar, N., Kumar, P., Kuznetsov, G., Lai, W.G., Larsen, N., Mackenzie, C., Martin, L.A., Melchers, D., Moriarty, A., Nguyen, T.V., Norris, J., O'Shea, M., Pancholi, S., Prajapati, S., Rajagopalan, S., Reynolds, D.J., Rimkunas, V., Rioux, N., Ribas, R., Siu, A., Sivakumar, S., Subramanian, V., Thomas, M., Vaillancourt, F.H., Wang, J., Wardell, S., Wick, M.J., Yao, S., Yu, L., Warmuth, M., Smith, P.G., Zhu, P., Korpal, M.
Cancer Discov
HeaderNuclear Protein/Antagonist
Released2018-02-23
Resolution1.890
CATH Insert Date03 Jun, 2018

PDB Images (3)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 03 Jun, 2018 Chopped

CATH Domains (1)

Domain ID Date inserted into CATH Superfamily CATH Status
6chwA00 28 Jun, 2018 1.10.565.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P03372 ESR1_HUMAN Homo sapiens Estrogen receptor