PDB 6bn5

PDB Information

PDB6BN5
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2.
LaRochelle, J.R., Fodor, M., Ellegast, J.M., Liu, X., Vemulapalli, V., Mohseni, M., Stams, T., Buhrlage, S.J., Stegmaier, K., LaMarche, M.J., Acker, M.G., Blacklow, S.C.
Bioorg. Med. Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2017-11-16
Resolution2.220
CATH Insert Date07 Jan, 2018

PDB Images (9)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 07 Jan, 2018 Chopped
B 07 Jan, 2018 Chopped

CATH Domains (6)

Domain ID Date inserted into CATH Superfamily CATH Status
6bn5A01 11 Jan, 2018 3.30.505.10 Assigned
6bn5A02 11 Jan, 2018 3.30.505.10 Assigned
6bn5A03 11 Jan, 2018 3.90.190.10 Assigned
6bn5B01 11 Jan, 2018 3.30.505.10 Assigned
6bn5B02 11 Jan, 2018 3.30.505.10 Assigned
6bn5B03 11 Jan, 2018 3.90.190.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q06124 PTN11_HUMAN Homo sapiens Tyrosine-protein phosphatase non-receptor type 11
Q06124 PTN11_HUMAN Homo sapiens Tyrosine-protein phosphatase non-receptor type 11