PDB 6bky

PDB Information

PDB6BKY
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315.
Jakob, C.G., Upadhyay, A.K., Donner, P.L., Nicholl, E., Addo, S.N., Qiu, W., Ling, C., Gopalakrishnan, S.M., Torrent, M., Cepa, S.P., Shanley, J., Shoemaker, A.R., Sun, C.C., Vasudevan, A., Woller, K.R., Shotwell, J.B., Shaw, B., Bian, Z., Hutti, J.E.
J. Med. Chem.
HeaderOxidoreductase/Oxidoreductase Inhibitor
Released2017-11-09
Resolution2.170
CATH Insert Date29 Jul, 2018

PDB Images (13)

PDB Prints

PDB Chains (6)

Chain ID Date inserted into CATH CATH Status
A 29 Jul, 2018 Chopped
B 29 Jul, 2018 Chopped
C 29 Jul, 2018 Chopped
D 29 Jul, 2018 Chopped
E 29 Jul, 2018 Chopped
F 29 Jul, 2018 Chopped

CATH Domains (6)

Domain ID Date inserted into CATH Superfamily CATH Status
6bkyA00 30 Jul, 2018 3.40.718.10 Assigned
6bkyB00 30 Jul, 2018 3.40.718.10 Assigned
6bkyC00 30 Jul, 2018 3.40.718.10 Assigned
6bkyD00 30 Jul, 2018 3.40.718.10 Assigned
6bkyE00 30 Jul, 2018 3.40.718.10 Assigned
6bkyF00 30 Jul, 2018 3.40.718.10 Assigned

UniProtKB Entries (6)

Accession Gene ID Taxon Description
O75874 IDHC_HUMAN Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic
O75874 IDHC_HUMAN Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic
O75874 IDHC_HUMAN Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic
O75874 IDHC_HUMAN Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic
O75874 IDHC_HUMAN Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic
O75874 IDHC_HUMAN Homo sapiens Isocitrate dehydrogenase [NADP] cytoplasmic