Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.
Vidadala, R.S., Rivas, K.L., Ojo, K.K., Hulverson, M.A., Zambriski, J.A., Bruzual, I., Schultz, T.L., Huang, W., Zhang, Z., Scheele, S., DeRocher, A.E., Choi, R., Barrett, L.K., Siddaramaiah, L.K., Hol, W.G., Fan, E., Merritt, E.A., Parsons, M., Freiberg, G., Marsh, K., Kempf, D.J., Carruthers, V.B., Isoherranen, N., Doggett, J.S., Van Voorhis, W.C., Maly, D.J.
J. Med. Chem.