PDB 6b0z

PDB Links
Overview

PDB Information

PDB	6B0Z
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor. Cho, Y.S., Levell, J.R., Liu, G., Caferro, T., Sutton, J., Shafer, C.M., Costales, A., Manning, J.R., Zhao, Q., Sendzik, M., Shultz, M., Chenail, G., Dooley, J., Villalba, B., Farsidjani, A., Chen, J., Kulathila, R., Xie, X., Dodd, S., Gould, T., Liang, G., Heimbach, T., Slocum, K., Firestone, B., Pu, M., Pagliarini, R., Growney, J.D. ACS Med Chem Lett
Header	Oxidoreductase
Released	2017-09-15
Resolution	2.330
CATH Insert Date	17 Dec, 2017

PDB Images (9)

Image of CATH 6b0z

6b0z

PDB 6b0z

Image of CATH 6b0zA

6b0zA

PDB Chain 6b0zA

Image of CATH 6b0zB

6b0zB

PDB Chain 6b0zB

Image of CATH 6b0zC

6b0zC

PDB Chain 6b0zC

Image of CATH 6b0zD

6b0zD

PDB Chain 6b0zD

Image of CATH 6b0zA00

6b0zA00

CATH Domain 6b0zA00

Image of CATH 6b0zB00

6b0zB00

CATH Domain 6b0zB00

Image of CATH 6b0zC00

6b0zC00

CATH Domain 6b0zC00

Image of CATH 6b0zD00

6b0zD00

CATH Domain 6b0zD00

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	17 Dec, 2017	Chopped
B	17 Dec, 2017	Chopped
C	17 Dec, 2017	Chopped
D	17 Dec, 2017	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6b0zA00	23 Dec, 2017	3.40.718.10	Assigned
6b0zB00	23 Dec, 2017	3.40.718.10	Assigned
6b0zC00	23 Dec, 2017	3.40.718.10	Assigned
6b0zD00	23 Dec, 2017	3.40.718.10	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
O75874	IDHC_HUMAN	Homo sapiens	Isocitrate dehydrogenase [NADP] cytoplasmic
O75874	IDHC_HUMAN	Homo sapiens	Isocitrate dehydrogenase [NADP] cytoplasmic
O75874	IDHC_HUMAN	Homo sapiens	Isocitrate dehydrogenase [NADP] cytoplasmic
O75874	IDHC_HUMAN	Homo sapiens	Isocitrate dehydrogenase [NADP] cytoplasmic