PDB 6acb

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Overview

PDB Information

PDB	6ACB
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli BL21
Gene Source	Homo sapiens
Primary Citation	Optimization of Chromeno[2,3- c]pyrrol-9(2 H)-ones as Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure-Activity Relationship, X-ray Crystal Structure, and Pharmacodynamic Effect on Pulmonary Arterial Hypertension. Wu, D., Huang, Y., Chen, Y., Huang, Y.Y., Geng, H., Zhang, T., Zhang, C., Li, Z., Guo, L., Chen, J., Luo, H.B. J. Med. Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2018-07-26
Resolution	2.800
CATH Insert Date	23 Sep, 2018

PDB Images (3)

Image of CATH 6acb

6acb

PDB 6acb

Image of CATH 6acbA

6acbA

PDB Chain 6acbA

Image of CATH 6acbA00

6acbA00

CATH Domain 6acbA00

PDB Prints

PDB Chains (1)

Chain ID	Date inserted into CATH	CATH Status
A	23 Sep, 2018	Chopped

CATH Domains (1)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6acbA00	24 Sep, 2018	1.10.1300.10	Assigned

UniProtKB Entries (1)

Accession	Gene ID	Taxon	Description
O76074	PDE5A_HUMAN	Homo sapiens	cGMP-specific 3',5'-cyclic phosphodiesterase