PDB 5zr3

PDB Links
Overview

PDB Information

PDB	5ZR3
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli BL21(DE3)
Gene Source	Homo sapiens
Primary Citation	Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1 H-pyrazol-4-yl)-1 H-imidazol-1-yl)-1 H-pyrazolo[3,4- b]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor. Uno, T., Kawai, Y., Yamashita, S., Oshiumi, H., Yoshimura, C., Mizutani, T., Suzuki, T., Chong, K.T., Shigeno, K., Ohkubo, M., Kodama, Y., Muraoka, H., Funabashi, K., Takahashi, K., Ohkubo, S., Kitade, M. J. Med. Chem.
Header	Chaperone
Released	2018-04-23
Resolution	2.500
CATH Insert Date	06 Jan, 2019

PDB Images (9)

Image of CATH 5zr3

5zr3

PDB 5zr3

Image of CATH 5zr3A

5zr3A

PDB Chain 5zr3A

Image of CATH 5zr3C

5zr3C

PDB Chain 5zr3C

Image of CATH 5zr3E

5zr3E

PDB Chain 5zr3E

Image of CATH 5zr3G

5zr3G

PDB Chain 5zr3G

Image of CATH 5zr3A00

5zr3A00

CATH Domain 5zr3A00

Image of CATH 5zr3C00

5zr3C00

CATH Domain 5zr3C00

Image of CATH 5zr3E00

5zr3E00

CATH Domain 5zr3E00

Image of CATH 5zr3G00

5zr3G00

CATH Domain 5zr3G00

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	06 Jan, 2019	Chopped
C	06 Jan, 2019	Chopped
E	06 Jan, 2019	Chopped
G	06 Jan, 2019	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5zr3A00	07 Jan, 2019	3.30.565.10	Assigned
5zr3C00	07 Jan, 2019	3.30.565.10	Assigned
5zr3E00	07 Jan, 2019	3.30.565.10	Assigned
5zr3G00	07 Jan, 2019	3.30.565.10	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
P07900	HS90A_HUMAN	Homo sapiens	Heat shock protein HSP 90-alpha
P07900	HS90A_HUMAN	Homo sapiens	Heat shock protein HSP 90-alpha
P07900	HS90A_HUMAN	Homo sapiens	Heat shock protein HSP 90-alpha
P07900	HS90A_HUMAN	Homo sapiens	Heat shock protein HSP 90-alpha