PDB Information

PDB5WMA
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor.
Ozer, H.G., El-Gamal, D., Powell, B., Hing, Z.A., Blachly, J.S., Harrington, B., Mitchell, S., Grieselhuber, N.R., Williams, K., Lai, T.H., Alinari, L., Baiocchi, R.A., Brinton, L., Baskin, E., Cannon, M., Beaver, L., Goettl, V.M., Lucas, D.M., Woyach, J.A., Sampath, D., Lehman, A.M., Yu, L., Zhang, J., Ma, Y., Zhang, Y., Spevak, W., Shi, S., Severson, P., Shellooe, R., Carias, H., Tsang, G., Dong, K., Ewing, T., Marimuthu, A., Tantoy, C., Walters, J., Sanftner, L., Rezaei, H., Nespi, M., Matusow, B., Habets, G., Ibrahim, P., Zhang, C., Mathe, E.A., Bollag, G., Byrd, J.C., Lapalombella, R.
Cancer Discov
HeaderTranscription/Transcription Inhibitor
Released2017-07-28
Resolution1.400
CATH Insert Date05 Aug, 2018

PDB Images (3)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 05 Aug, 2018 Chopped

CATH Domains (1)

Domain ID Date inserted into CATH Superfamily CATH Status
5wmaA01 06 Aug, 2018 1.20.920.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
O60885 BRD4_HUMAN Homo sapiens Bromodomain-containing protein 4