PDB 5wkm

PDB Information

PDB5WKM
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceMiddle East respiratory syndrome-related coronavirus
Primary Citation
Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.
Galasiti Kankanamalage, A.C., Kim, Y., Damalanka, V.C., Rathnayake, A.D., Fehr, A.R., Mehzabeen, N., Battaile, K.P., Lovell, S., Lushington, G.H., Perlman, S., Chang, K.O., Groutas, W.C.
Eur J Med Chem
HeaderHydrolase/Hydrolase Inhibitor
Released2017-07-25
Resolution2.250
CATH Insert Date03 Jun, 2018

PDB Images (5)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 03 Jun, 2018 Chopped

CATH Domains (3)

Domain ID Date inserted into CATH Superfamily CATH Status
5wkmA01 28 Jun, 2018 2.40.10.10 Assigned
5wkmA02 28 Jun, 2018 2.40.10.10 Assigned
5wkmA03 28 Jun, 2018 1.10.1840.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
K9N638 R1A_CVEMC Betacoronavirus England 1 Replicase polyprotein 1a