PDB 5we8

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Overview

PDB Information

PDB	5WE8
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models. Yamada, K., Levell, J., Yoon, T., Kohls, D., Yowe, D., Rigel, D.F., Imase, H., Yuan, J., Yasoshima, K., DiPetrillo, K., Monovich, L., Xu, L., Zhu, M., Kato, M., Jain, M., Idamakanti, N., Taslimi, P., Kawanami, T., Argikar, U.A., Kunjathoor, V., Xie, X., Yagi, Y.I., Iwaki, Y., Robinson, Z., Park, H.M. J. Med. Chem.
Header	Transferase/Transferase Inhibitor
Released	2017-07-07
Resolution	2.010
CATH Insert Date	14 Nov, 2017

PDB Images (7)

Image of CATH 5we8

5we8

PDB 5we8

Image of CATH 5we8A

5we8A

PDB Chain 5we8A

Image of CATH 5we8B

5we8B

PDB Chain 5we8B

Image of CATH 5we8A01

5we8A01

CATH Domain 5we8A01

Image of CATH 5we8A02

5we8A02

CATH Domain 5we8A02

Image of CATH 5we8B01

5we8B01

CATH Domain 5we8B01

Image of CATH 5we8B02

5we8B02

CATH Domain 5we8B02

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	14 Nov, 2017	Chopped
B	14 Nov, 2017	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5we8A01	05 Apr, 2018	3.30.200.20	Assigned
5we8A02	05 Apr, 2018	1.10.510.10	Assigned
5we8B01	05 Apr, 2018	3.30.200.20	Assigned
5we8B02	05 Apr, 2018	1.10.510.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
Q9H4A3	WNK1_HUMAN	Homo sapiens	Serine/threonine-protein kinase WNK1
Q9H4A3	WNK1_HUMAN	Homo sapiens	Serine/threonine-protein kinase WNK1