PDB 5w5o

PDB Information

PDB5W5O
MethodX-RAY DIFFRACTION
Host Organismunidentified baculovirus
Gene SourceHomo sapiens
Primary Citation
Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases.
He, X., Da Ros, S., Nelson, J., Zhu, X., Jiang, T., Okram, B., Jiang, S., Michellys, P.Y., Iskandar, M., Espinola, S., Jia, Y., Bursulaya, B., Kreusch, A., Gao, M.Y., Spraggon, G., Baaten, J., Clemmer, L., Meeusen, S., Huang, D., Hill, R., Nguyen-Tran, V., Fathman, J., Liu, B., Tuntland, T., Gordon, P., Hollenbeck, T., Ng, K., Shi, J., Bordone, L., Liu, H.
ACS Med Chem Lett
HeaderTransferase/Transferase Inhibitor
Released2017-06-15
Resolution2.890
CATH Insert Date14 Nov, 2017

PDB Images (33)

PDB Prints

PDB Chains (16)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped
C 14 Nov, 2017 Chopped
D 14 Nov, 2017 Chopped
E 14 Nov, 2017 Chopped
F 14 Nov, 2017 Chopped
G 14 Nov, 2017 Chopped
H 14 Nov, 2017 Chopped
I 14 Nov, 2017 Chopped
J 14 Nov, 2017 Chopped
K 14 Nov, 2017 Chopped
L 14 Nov, 2017 Chopped
M 14 Nov, 2017 Chopped
N 14 Nov, 2017 Chopped
O 14 Nov, 2017 Chopped
P 14 Nov, 2017 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
5w5oA00 16 Dec, 2017 1.10.510.10 Assigned
5w5oB00 16 Dec, 2017 1.10.510.10 Assigned
5w5oC00 16 Dec, 2017 1.10.510.10 Assigned
5w5oD00 16 Dec, 2017 1.10.510.10 Assigned
5w5oE00 16 Dec, 2017 1.10.510.10 Assigned
5w5oF00 16 Dec, 2017 1.10.510.10 Assigned
5w5oG00 16 Dec, 2017 1.10.510.10 Assigned
5w5oH00 16 Dec, 2017 1.10.510.10 Assigned
5w5oI00 16 Dec, 2017 1.10.510.10 Assigned
5w5oJ00 16 Dec, 2017 1.10.510.10 Assigned
5w5oK00 16 Dec, 2017 1.10.510.10 Assigned
5w5oL00 16 Dec, 2017 1.10.510.10 Assigned
5w5oM00 16 Dec, 2017 1.10.510.10 Assigned
5w5oN00 16 Dec, 2017 1.10.510.10 Assigned
5w5oO00 16 Dec, 2017 1.10.510.10 Assigned
5w5oP00 16 Dec, 2017 1.10.510.10 Assigned

UniProtKB Entries (16)

Accession Gene ID Taxon Description
O43353 RIPK2_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 2
O43353 RIPK2_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 2
O43353 RIPK2_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 2
O43353 RIPK2_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 2
O43353 RIPK2_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 2
O43353 RIPK2_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 2
O43353 RIPK2_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 2
O43353 RIPK2_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 2
O43353 RIPK2_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 2
O43353 RIPK2_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 2
O43353 RIPK2_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 2
O43353 RIPK2_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 2
O43353 RIPK2_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 2
O43353 RIPK2_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 2
O43353 RIPK2_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 2
O43353 RIPK2_HUMAN Homo sapiens Receptor-interacting serine/threonine-protein kinase 2