PDB 5w5o

PDB Links
Overview

PDB Information

PDB	5W5O
Method	X-RAY DIFFRACTION
Host Organism	unidentified baculovirus
Gene Source	Homo sapiens
Primary Citation	Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases. He, X., Da Ros, S., Nelson, J., Zhu, X., Jiang, T., Okram, B., Jiang, S., Michellys, P.Y., Iskandar, M., Espinola, S., Jia, Y., Bursulaya, B., Kreusch, A., Gao, M.Y., Spraggon, G., Baaten, J., Clemmer, L., Meeusen, S., Huang, D., Hill, R., Nguyen-Tran, V., Fathman, J., Liu, B., Tuntland, T., Gordon, P., Hollenbeck, T., Ng, K., Shi, J., Bordone, L., Liu, H. ACS Med Chem Lett
Header	Transferase/Transferase Inhibitor
Released	2017-06-15
Resolution	2.890
CATH Insert Date	14 Nov, 2017

PDB Images (33)

5w5o

PDB 5w5o

5w5oA

PDB Chain 5w5oA

5w5oB

PDB Chain 5w5oB

5w5oC

PDB Chain 5w5oC

5w5oD

PDB Chain 5w5oD

5w5oE

PDB Chain 5w5oE

5w5oF

PDB Chain 5w5oF

5w5oG

PDB Chain 5w5oG

5w5oH

PDB Chain 5w5oH

5w5oI

PDB Chain 5w5oI

5w5oJ

PDB Chain 5w5oJ

5w5oK

PDB Chain 5w5oK

5w5oL

PDB Chain 5w5oL

5w5oM

PDB Chain 5w5oM

5w5oN

PDB Chain 5w5oN

5w5oO

PDB Chain 5w5oO

5w5oP

PDB Chain 5w5oP

5w5oA00

CATH Domain 5w5oA00

5w5oB00

CATH Domain 5w5oB00

5w5oC00

CATH Domain 5w5oC00

5w5oD00

CATH Domain 5w5oD00

5w5oE00

CATH Domain 5w5oE00

5w5oF00

CATH Domain 5w5oF00

5w5oG00

CATH Domain 5w5oG00

5w5oH00

CATH Domain 5w5oH00

5w5oI00

CATH Domain 5w5oI00

5w5oJ00

CATH Domain 5w5oJ00

5w5oK00

CATH Domain 5w5oK00

5w5oL00

CATH Domain 5w5oL00

5w5oM00

CATH Domain 5w5oM00

5w5oN00

CATH Domain 5w5oN00

5w5oO00

CATH Domain 5w5oO00

5w5oP00

CATH Domain 5w5oP00

PDB Prints

PDB Chains (16)

Chain ID	Date inserted into CATH	CATH Status
A	14 Nov, 2017	Chopped
B	14 Nov, 2017	Chopped
C	14 Nov, 2017	Chopped
D	14 Nov, 2017	Chopped
E	14 Nov, 2017	Chopped
F	14 Nov, 2017	Chopped
G	14 Nov, 2017	Chopped
H	14 Nov, 2017	Chopped
I	14 Nov, 2017	Chopped
J	14 Nov, 2017	Chopped
K	14 Nov, 2017	Chopped
L	14 Nov, 2017	Chopped
M	14 Nov, 2017	Chopped
N	14 Nov, 2017	Chopped
O	14 Nov, 2017	Chopped
P	14 Nov, 2017	Chopped

CATH Domains (16)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5w5oA00	16 Dec, 2017	1.10.510.10	Assigned
5w5oB00	16 Dec, 2017	1.10.510.10	Assigned
5w5oC00	16 Dec, 2017	1.10.510.10	Assigned
5w5oD00	16 Dec, 2017	1.10.510.10	Assigned
5w5oE00	16 Dec, 2017	1.10.510.10	Assigned
5w5oF00	16 Dec, 2017	1.10.510.10	Assigned
5w5oG00	16 Dec, 2017	1.10.510.10	Assigned
5w5oH00	16 Dec, 2017	1.10.510.10	Assigned
5w5oI00	16 Dec, 2017	1.10.510.10	Assigned
5w5oJ00	16 Dec, 2017	1.10.510.10	Assigned
5w5oK00	16 Dec, 2017	1.10.510.10	Assigned
5w5oL00	16 Dec, 2017	1.10.510.10	Assigned
5w5oM00	16 Dec, 2017	1.10.510.10	Assigned
5w5oN00	16 Dec, 2017	1.10.510.10	Assigned
5w5oO00	16 Dec, 2017	1.10.510.10	Assigned
5w5oP00	16 Dec, 2017	1.10.510.10	Assigned

UniProtKB Entries (16)

Accession	Gene ID	Taxon	Description
O43353	RIPK2_HUMAN	Homo sapiens	Receptor-interacting serine/threonine-protein kinase 2
O43353	RIPK2_HUMAN	Homo sapiens	Receptor-interacting serine/threonine-protein kinase 2
O43353	RIPK2_HUMAN	Homo sapiens	Receptor-interacting serine/threonine-protein kinase 2
O43353	RIPK2_HUMAN	Homo sapiens	Receptor-interacting serine/threonine-protein kinase 2
O43353	RIPK2_HUMAN	Homo sapiens	Receptor-interacting serine/threonine-protein kinase 2
O43353	RIPK2_HUMAN	Homo sapiens	Receptor-interacting serine/threonine-protein kinase 2
O43353	RIPK2_HUMAN	Homo sapiens	Receptor-interacting serine/threonine-protein kinase 2
O43353	RIPK2_HUMAN	Homo sapiens	Receptor-interacting serine/threonine-protein kinase 2
O43353	RIPK2_HUMAN	Homo sapiens	Receptor-interacting serine/threonine-protein kinase 2
O43353	RIPK2_HUMAN	Homo sapiens	Receptor-interacting serine/threonine-protein kinase 2
O43353	RIPK2_HUMAN	Homo sapiens	Receptor-interacting serine/threonine-protein kinase 2
O43353	RIPK2_HUMAN	Homo sapiens	Receptor-interacting serine/threonine-protein kinase 2
O43353	RIPK2_HUMAN	Homo sapiens	Receptor-interacting serine/threonine-protein kinase 2
O43353	RIPK2_HUMAN	Homo sapiens	Receptor-interacting serine/threonine-protein kinase 2
O43353	RIPK2_HUMAN	Homo sapiens	Receptor-interacting serine/threonine-protein kinase 2
O43353	RIPK2_HUMAN	Homo sapiens	Receptor-interacting serine/threonine-protein kinase 2