PDB 5vpm

PDB Information

PDB5VPM
MethodX-RAY DIFFRACTION
Host OrganismHomo sapiens
Gene SourceHomo sapiens
Primary Citation
Discovery of renin inhibitors containing a simple aspartate binding moiety that imparts reduced P450 inhibition.
Lawhorn, B.G., Tran, T., Hong, V.S., Morgan, L.A., Le, B.T., Harpel, M.R., Jolivette, L., Diaz, E., Schwartz, B., Gross, J.W., Tomaszek, T., Semus, S., Concha, N., Smallwood, A., Holt, D.A., Kallander, L.S.
Bioorg. Med. Chem. Lett.
HeaderHydrolase/Hydrolase Inhibitor
Released2017-05-05
Resolution2.900
CATH Insert Date14 Nov, 2017

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
5vpmA01 10 Dec, 2017 2.40.70.10 Assigned
5vpmA02 10 Dec, 2017 2.40.70.10 Assigned
5vpmB01 10 Dec, 2017 2.40.70.10 Assigned
5vpmB02 10 Dec, 2017 2.40.70.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P00797 RENI_HUMAN Homo sapiens Renin
P00797 RENI_HUMAN Homo sapiens Renin