PDB 5vp1

PDB Links
Overview

PDB Information

PDB	5VP1
Method	X-RAY DIFFRACTION
Host Organism	Baculovirus expression vector pFastBac1-HM
Gene Source	Homo sapiens
Primary Citation	Discovery of a Novel Series of Pyrazolo[1,5-a]pyrimidine-Based Phosphodiesterase 2A Inhibitors Structurally Different from N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), for the Treatment of Cognitive Disorders. Mikami, S., Kawasaki, M., Ikeda, S., Negoro, N., Nakamura, S., Nomura, I., Ashizawa, T., Kokubo, H., Hoffman, I.D., Zou, H., Oki, H., Uchiyama, N., Hiura, Y., Miyamoto, M., Itou, Y., Nakashima, M., Iwashita, H., Taniguchi, T. Chem. Pharm. Bull.
Header	Hydrolase/Hydrolase Inhibitor
Released	2017-05-03
Resolution	1.860
CATH Insert Date	07 Jan, 2018

PDB Images (7)

Image of CATH 5vp1

5vp1

PDB 5vp1

Image of CATH 5vp1A

5vp1A

PDB Chain 5vp1A

Image of CATH 5vp1B

5vp1B

PDB Chain 5vp1B

Image of CATH 5vp1C

5vp1C

PDB Chain 5vp1C

Image of CATH 5vp1A00

5vp1A00

CATH Domain 5vp1A00

Image of CATH 5vp1B00

5vp1B00

CATH Domain 5vp1B00

Image of CATH 5vp1C00

5vp1C00

CATH Domain 5vp1C00

PDB Prints

PDB Chains (3)

Chain ID	Date inserted into CATH	CATH Status
A	07 Jan, 2018	Chopped
B	07 Jan, 2018	Chopped
C	07 Jan, 2018	Chopped

CATH Domains (3)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5vp1A00	11 Jan, 2018	1.10.1300.10	Assigned
5vp1B00	11 Jan, 2018	1.10.1300.10	Assigned
5vp1C00	11 Jan, 2018	1.10.1300.10	Assigned

UniProtKB Entries (3)

Accession	Gene ID	Taxon	Description
O00408	PDE2A_HUMAN	Homo sapiens	cGMP-dependent 3',5'-cyclic phosphodiesterase
O00408	PDE2A_HUMAN	Homo sapiens	cGMP-dependent 3',5'-cyclic phosphodiesterase
O00408	PDE2A_HUMAN	Homo sapiens	cGMP-dependent 3',5'-cyclic phosphodiesterase