PDB 5uy8

PDB Information

PDB5UY8
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model.
Fales, K.R., Njoroge, F.G., Brooks, H.B., Thibodeaux, S., Torrado, A., Si, C., Toth, J.L., Mc Cowan, J.R., Roth, K.D., Thrasher, K.J., Frimpong, K., Lee, M.R., Dally, R.D., Shepherd, T.A., Durham, T.B., Margolis, B.J., Wu, Z., Wang, Y., Atwell, S., Wang, J., Hui, Y.H., Meier, T.I., Konicek, S.A., Geeganage, S.
J. Med. Chem.
HeaderTransferase, Hydrolase
Released2017-02-23
Resolution2.390
CATH Insert Date03 Jun, 2018

PDB Images (21)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 03 Jun, 2018 Chopped
B 03 Jun, 2018 Chopped
C 03 Jun, 2018 Chopped
D 03 Jun, 2018 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
5uy8A01 28 Jun, 2018 3.40.50.1380 Assigned
5uy8A02 28 Jun, 2018 3.40.140.20 Assigned
5uy8A03 28 Jun, 2018 3.40.140.20 Assigned
5uy8A04 28 Jun, 2018 1.10.287.440 Assigned
5uy8B01 28 Jun, 2018 3.40.50.1380 Assigned
5uy8B02 28 Jun, 2018 3.40.140.20 Assigned
5uy8B03 28 Jun, 2018 3.40.140.20 Assigned
5uy8B04 28 Jun, 2018 1.10.287.440 Assigned
5uy8C01 28 Jun, 2018 3.40.50.1380 Assigned
5uy8C02 28 Jun, 2018 3.40.140.20 Assigned
5uy8C03 28 Jun, 2018 3.40.140.20 Assigned
5uy8C04 28 Jun, 2018 1.10.287.440 Assigned
5uy8D01 28 Jun, 2018 3.40.50.1380 Assigned
5uy8D02 28 Jun, 2018 3.40.140.20 Assigned
5uy8D03 28 Jun, 2018 3.40.140.20 Assigned
5uy8D04 28 Jun, 2018 1.10.287.440 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
P31939 PUR9_HUMAN Homo sapiens Bifunctional purine biosynthesis protein PURH
P31939 PUR9_HUMAN Homo sapiens Bifunctional purine biosynthesis protein PURH
P31939 PUR9_HUMAN Homo sapiens Bifunctional purine biosynthesis protein PURH
P31939 PUR9_HUMAN Homo sapiens Bifunctional purine biosynthesis protein PURH