PDB Information

PDB5UPE
MethodX-RAY DIFFRACTION
Host OrganismMammalia
Gene SourceHomo sapiens
Primary Citation
SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT).
Curtin, M.L., Heyman, H.R., Clark, R.F., Sorensen, B.K., Doherty, G.A., Hansen, T.M., Frey, R.R., Sarris, K.A., Aguirre, A.L., Shrestha, A., Tu, N., Woller, K., Pliushchev, M.A., Sweis, R.F., Cheng, M., Wilsbacher, J.L., Kovar, P.J., Guo, J., Cheng, D., Longenecker, K.L., Raich, D., Korepanova, A.V., Soni, N.B., Algire, M.A., Richardson, P.L., Marin, V.L., Badagnani, I., Vasudevan, A., Buchanan, F.G., Maag, D., Chiang, G.G., Tse, C., Michaelides, M.R.
Bioorg. Med. Chem. Lett.
HeaderTransferase/Transferase Inhibitor
Released2017-02-02
Resolution1.930
CATH Insert Date14 Nov, 2017

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
5upeA01 10 Dec, 2017 Holding pen
5upeA02 10 Dec, 2017 3.20.20.70 Assigned
5upeB01 10 Dec, 2017 Holding pen
5upeB02 10 Dec, 2017 3.20.20.70 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P43490 NAMPT_HUMAN Homo sapiens Nicotinamide phosphoribosyltransferase
P43490 NAMPT_HUMAN Homo sapiens Nicotinamide phosphoribosyltransferase