PDB 5uf0

PDB Information

PDB5UF0
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli-Pichia pastoris shuttle vector pPpARG4
Gene SourceHomo sapiens
Primary Citation
Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.
Wang, L., Pratt, J.K., Soltwedel, T., Sheppard, G.S., Fidanze, S.D., Liu, D., Hasvold, L.A., Mantei, R.A., Holms, J.H., McClellan, W.J., Wendt, M.D., Wada, C., Frey, R., Hansen, T.M., Hubbard, R., Park, C.H., Li, L., Magoc, T.J., Albert, D.H., Lin, X., Warder, S.E., Kovar, P., Huang, X., Wilcox, D., Wang, R., Rajaraman, G., Petros, A.M., Hutchins, C.W., Panchal, S.C., Sun, C., Elmore, S.W., Shen, Y., Kati, W.M., McDaniel, K.F.
J. Med. Chem.
HeaderSignaling Protein/Inhibitor
Released2017-01-03
Resolution1.350
CATH Insert Date14 Nov, 2017

PDB Images (3)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped

CATH Domains (1)

Domain ID Date inserted into CATH Superfamily CATH Status
5uf0A00 10 Dec, 2017 1.20.920.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
O60885 BRD4_HUMAN Homo sapiens Bromodomain-containing protein 4