PDB 5u7i

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Overview

PDB Information

PDB	5U7I
Method	X-RAY DIFFRACTION
Host Organism	Spodoptera frugiperda
Gene Source	Homo sapiens
Primary Citation	Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor. Helal, C.J., Arnold, E.P., Boyden, T.L., Chang, C., Chappie, T.A., Fennell, K.F., Forman, M.D., Hajos, M., Harms, J.F., Hoffman, W.E., Humphrey, J.M., Kang, Z., Kleiman, R.J., Kormos, B.L., Lee, C.W., Lu, J., Maklad, N., McDowell, L., Mente, S., O'Connor, R.E., Pandit, J., Piotrowski, M., Schmidt, A.W., Schmidt, C.J., Ueno, H., Verhoest, P.R., Yang, E.X. J. Med. Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2016-12-12
Resolution	2.000
CATH Insert Date	14 Nov, 2017

PDB Images (9)

Image of CATH 5u7i

5u7i

PDB 5u7i

Image of CATH 5u7iA

5u7iA

PDB Chain 5u7iA

Image of CATH 5u7iB

5u7iB

PDB Chain 5u7iB

Image of CATH 5u7iC

5u7iC

PDB Chain 5u7iC

Image of CATH 5u7iD

5u7iD

PDB Chain 5u7iD

Image of CATH 5u7iA00

5u7iA00

CATH Domain 5u7iA00

Image of CATH 5u7iB00

5u7iB00

CATH Domain 5u7iB00

Image of CATH 5u7iC00

5u7iC00

CATH Domain 5u7iC00

Image of CATH 5u7iD00

5u7iD00

CATH Domain 5u7iD00

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	14 Nov, 2017	Chopped
B	14 Nov, 2017	Chopped
C	14 Nov, 2017	Chopped
D	14 Nov, 2017	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5u7iA00	10 Dec, 2017	1.10.1300.10	Assigned
5u7iB00	10 Dec, 2017	1.10.1300.10	Assigned
5u7iC00	10 Dec, 2017	1.10.1300.10	Assigned
5u7iD00	10 Dec, 2017	1.10.1300.10	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
O00408	PDE2A_HUMAN	Homo sapiens	cGMP-dependent 3',5'-cyclic phosphodiesterase
O00408	PDE2A_HUMAN	Homo sapiens	cGMP-dependent 3',5'-cyclic phosphodiesterase
O00408	PDE2A_HUMAN	Homo sapiens	cGMP-dependent 3',5'-cyclic phosphodiesterase
O00408	PDE2A_HUMAN	Homo sapiens	cGMP-dependent 3',5'-cyclic phosphodiesterase