PDB Information

PDB5U62
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli K-12
Gene SourceHomo sapiens
Primary Citation
Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase.
Lingel, A., Sendzik, M., Huang, Y., Shultz, M.D., Cantwell, J., Dillon, M.P., Fu, X., Fuller, J., Gabriel, T., Gu, J., Jiang, X., Li, L., Liang, F., McKenna, M., Qi, W., Rao, W., Sheng, X., Shu, W., Sutton, J., Taft, B., Wang, L., Zeng, J., Zhang, H., Zhang, M., Zhao, K., Lindvall, M., Bussiere, D.E.
J. Med. Chem.
HeaderTranscription/Transferase
Released2016-12-07
Resolution1.900
CATH Insert Date07 May, 2017

PDB Images (7)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 08 May, 2017 Chopped
B 08 May, 2017 Chopped
C 08 May, 2017 Rejected
D 08 May, 2017 Rejected

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
5u62A00 14 Dec, 2017 2.130.10.10 Assigned
5u62B00 14 Dec, 2017 2.130.10.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
O75530 EED_HUMAN Homo sapiens Polycomb protein EED
Q15910 EZH2_HUMAN Homo sapiens Histone-lysine N-methyltransferase EZH2
O75530 EED_HUMAN Homo sapiens Polycomb protein EED
Q15910 EZH2_HUMAN Homo sapiens Histone-lysine N-methyltransferase EZH2