PDB 5tx4

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Overview

PDB Information

PDB	5TX4
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	An engineered transforming growth factor beta (TGF-beta ) monomer that functions as a dominant negative to block TGF-beta signaling. Kim, S.K., Barron, L., Hinck, C.S., Petrunak, E.M., Cano, K.E., Thangirala, A., Iskra, B., Brothers, M., Vonberg, M., Leal, B., Richter, B., Kodali, R., Taylor, A.B., Du, S., Barnes, C.O., Sulea, T., Calero, G., Hart, P.J., Hart, M.J., Demeler, B., Hinck, A.P. J. Biol. Chem.
Header	Transferase/Cytokine
Released	2016-11-15
Resolution	1.880
CATH Insert Date	07 May, 2017

PDB Images (5)

Image of CATH 5tx4

5tx4

PDB 5tx4

Image of CATH 5tx4A

5tx4A

PDB Chain 5tx4A

Image of CATH 5tx4B

5tx4B

PDB Chain 5tx4B

Image of CATH 5tx4A00

5tx4A00

CATH Domain 5tx4A00

Image of CATH 5tx4B00

5tx4B00

CATH Domain 5tx4B00

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	08 May, 2017	Chopped
B	08 May, 2017	Chopped

CATH Domains (2)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5tx4A00	22 May, 2017	2.10.60.10	Assigned
5tx4B00	14 Dec, 2017	2.10.90.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
P61812	TGFB2_HUMAN	Homo sapiens	Transforming growth factor beta-2 proprotein
P37173	TGFR2_HUMAN	Homo sapiens	TGF-beta receptor type-2