PDB 5tx4

PDB Information

PDB5TX4
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
An engineered transforming growth factor beta (TGF-beta ) monomer that functions as a dominant negative to block TGF-beta signaling.
Kim, S.K., Barron, L., Hinck, C.S., Petrunak, E.M., Cano, K.E., Thangirala, A., Iskra, B., Brothers, M., Vonberg, M., Leal, B., Richter, B., Kodali, R., Taylor, A.B., Du, S., Barnes, C.O., Sulea, T., Calero, G., Hart, P.J., Hart, M.J., Demeler, B., Hinck, A.P.
J. Biol. Chem.
HeaderTransferase/Cytokine
Released2016-11-15
Resolution1.880
CATH Insert Date07 May, 2017

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 08 May, 2017 Chopped
B 08 May, 2017 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
5tx4A00 22 May, 2017 2.10.60.10 Assigned
5tx4B00 14 Dec, 2017 2.10.90.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P37173 TGFR2_HUMAN Homo sapiens TGF-beta receptor type-2
P61812 TGFB2_HUMAN Homo sapiens Transforming growth factor beta-2 proprotein