PDB 5tt7

PDB Information

PDB5TT7
MethodX-RAY DIFFRACTION
Host OrganismBaculovirus expression vector pFastBac1-HM
Gene SourceHomo sapiens
Primary Citation
Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK).
Lam, B., Arikawa, Y., Cramlett, J., Dong, Q., de Jong, R., Feher, V., Grimshaw, C.E., Farrell, P.J., Hoffman, I.D., Jennings, A., Jones, B., Matuszkiewicz, J., Miura, J., Miyake, H., Natala, S.R., Shi, L., Takahashi, M., Taylor, E., Wyrick, C., Yano, J., Zalevsky, J., Nie, Z.
Bioorg. Med. Chem. Lett.
HeaderTransferase/Transferase Inhibitor
Released2016-11-01
Resolution1.770
CATH Insert Date08 Jan, 2017

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 09 Jan, 2017 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
5tt7A01 20 Jan, 2017 3.30.200.20 Assigned
5tt7A02 20 Jan, 2017 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P43405 KSYK_HUMAN Homo sapiens Tyrosine-protein kinase SYK