PDB 5tq6

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Overview

PDB Information

PDB	5TQ6
Method	X-RAY DIFFRACTION
Host Organism	Homo sapiens
Gene Source	Homo sapiens
Primary Citation	Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin. Jones, P., Storer, R.I., Sabnis, Y.A., Wakenhut, F.M., Whitlock, G.A., England, K.S., Mukaiyama, T., Dehnhardt, C.M., Coe, J.W., Kortum, S.W., Chrencik, J.E., Brown, D.G., Jones, R.M., Murphy, J.R., Yeoh, T., Morgan, P., Kilty, I. J. Med. Chem.
Header	Transferase/Transferase Inhibitor
Released	2016-10-23
Resolution	2.060
CATH Insert Date	07 May, 2017

PDB Images (7)

Image of CATH 5tq6

5tq6

PDB 5tq6

Image of CATH 5tq6A

5tq6A

PDB Chain 5tq6A

Image of CATH 5tq6B

5tq6B

PDB Chain 5tq6B

Image of CATH 5tq6A01

5tq6A01

CATH Domain 5tq6A01

Image of CATH 5tq6A02

5tq6A02

CATH Domain 5tq6A02

Image of CATH 5tq6B01

5tq6B01

CATH Domain 5tq6B01

Image of CATH 5tq6B02

5tq6B02

CATH Domain 5tq6B02

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	08 May, 2017	Chopped
B	08 May, 2017	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5tq6A01	22 May, 2017	3.30.200.20	Assigned
5tq6A02	22 May, 2017	1.10.510.10	Assigned
5tq6B01	22 May, 2017	3.30.200.20	Assigned
5tq6B02	22 May, 2017	1.10.510.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
O60674	JAK2_HUMAN	Homo sapiens	Tyrosine-protein kinase JAK2
O60674	JAK2_HUMAN	Homo sapiens	Tyrosine-protein kinase JAK2