PDB 5to8

PDB Information

PDB5TO8
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency.
Farand, J., Mai, N., Chandrasekhar, J., Newby, Z.E., Van Veldhuizen, J., Loyer-Drew, J., Venkataramani, C., Guerrero, J., Kwok, A., Li, N., Zherebina, Y., Wilbert, S., Zablocki, J., Phillips, G., Watkins, W.J., Mourey, R., Notte, G.T.
Bioorg. Med. Chem. Lett.
HeaderTransferase/Transferase Inhibitor
Released2016-10-17
Resolution1.980
CATH Insert Date25 Dec, 2016

PDB Images (4)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 26 Dec, 2016 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
5to8A01 31 Dec, 2016 3.30.200.20 Assigned
5to8A02 31 Dec, 2016 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q14289 FAK2_HUMAN Homo sapiens Protein-tyrosine kinase 2-beta