PDB 5tkb

PDB Information

PDB5TKB
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling.
Moslin, R., Gardner, D., Santella, J., Zhang, Y., Duncia, J.V., Liu, C., Lin, J., Tokarski, J.S., Strnad, J., Pedicord, D., Chen, J., Blat, Y., Zupa-Fernandez, A., Cheng, L., Sun, H., Chaudhry, C., Huang, C., D'Arienzo, C., Sack, J.S., Muckelbauer, J.K., Chang, C., Tredup, J., Xie, D., Aranibar, N., Burke, J.R., Carter, P.H., Weinstein, D.S.
Medchemcomm
HeaderHydrolase/Hydrolase Inhibitor
Released2016-10-06
Resolution2.160
CATH Insert Date08 Jan, 2017

PDB Images (9)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 09 Jan, 2017 Chopped
B 09 Jan, 2017 Chopped
C 09 Jan, 2017 Chopped
D 09 Jan, 2017 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
5tkbA00 25 May, 2017 1.10.1300.10 Assigned
5tkbB00 25 May, 2017 1.10.1300.10 Assigned
5tkbC00 25 May, 2017 1.10.1300.10 Assigned
5tkbD00 25 May, 2017 1.10.1300.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
Q08499 PDE4D_HUMAN Homo sapiens cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Q08499 PDE4D_HUMAN Homo sapiens cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Q08499 PDE4D_HUMAN Homo sapiens cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Q08499 PDE4D_HUMAN Homo sapiens cAMP-specific 3',5'-cyclic phosphodiesterase 4D