PDB 5tkb

PDB Links
Overview

PDB Information

PDB	5TKB
Method	X-RAY DIFFRACTION
Host Organism	Spodoptera frugiperda
Gene Source	Homo sapiens
Primary Citation	Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling. Moslin, R., Gardner, D., Santella, J., Zhang, Y., Duncia, J.V., Liu, C., Lin, J., Tokarski, J.S., Strnad, J., Pedicord, D., Chen, J., Blat, Y., Zupa-Fernandez, A., Cheng, L., Sun, H., Chaudhry, C., Huang, C., D'Arienzo, C., Sack, J.S., Muckelbauer, J.K., Chang, C., Tredup, J., Xie, D., Aranibar, N., Burke, J.R., Carter, P.H., Weinstein, D.S. Medchemcomm
Header	Hydrolase/Hydrolase Inhibitor
Released	2016-10-06
Resolution	2.160
CATH Insert Date	08 Jan, 2017

PDB Images (9)

Image of CATH 5tkb

5tkb

PDB 5tkb

Image of CATH 5tkbA

5tkbA

PDB Chain 5tkbA

Image of CATH 5tkbB

5tkbB

PDB Chain 5tkbB

Image of CATH 5tkbC

5tkbC

PDB Chain 5tkbC

Image of CATH 5tkbD

5tkbD

PDB Chain 5tkbD

Image of CATH 5tkbA00

5tkbA00

CATH Domain 5tkbA00

Image of CATH 5tkbB00

5tkbB00

CATH Domain 5tkbB00

Image of CATH 5tkbC00

5tkbC00

CATH Domain 5tkbC00

Image of CATH 5tkbD00

5tkbD00

CATH Domain 5tkbD00

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	09 Jan, 2017	Chopped
B	09 Jan, 2017	Chopped
C	09 Jan, 2017	Chopped
D	09 Jan, 2017	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5tkbA00	25 May, 2017	1.10.1300.10	Assigned
5tkbB00	25 May, 2017	1.10.1300.10	Assigned
5tkbC00	25 May, 2017	1.10.1300.10	Assigned
5tkbD00	25 May, 2017	1.10.1300.10	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
Q08499	PDE4D_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Q08499	PDE4D_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Q08499	PDE4D_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Q08499	PDE4D_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4D