PDB 5tci

PDB Links
Overview

PDB Information

PDB	5TCI
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Primary Citation	A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase. Wellington, S., Nag, P.P., Michalska, K., Johnston, S.E., Jedrzejczak, R.P., Kaushik, V.K., Clatworthy, A.E., Siddiqi, N., McCarren, P., Bajrami, B., Maltseva, N.I., Combs, S., Fisher, S.L., Joachimiak, A., Schreiber, S.L., Hung, D.T. Nat. Chem. Biol.
Header	Lyase
Released	2016-09-15
Resolution	2.450
CATH Insert Date	14 Nov, 2017

PDB Images (21)

5tci

PDB 5tci

5tciA

PDB Chain 5tciA

5tciB

PDB Chain 5tciB

5tciC

PDB Chain 5tciC

5tciD

PDB Chain 5tciD

5tciE

PDB Chain 5tciE

5tciF

PDB Chain 5tciF

5tciG

PDB Chain 5tciG

5tciH

PDB Chain 5tciH

5tciA00

CATH Domain 5tciA00

5tciB01

CATH Domain 5tciB01

5tciB02

CATH Domain 5tciB02

5tciC00

CATH Domain 5tciC00

5tciD01

CATH Domain 5tciD01

5tciD02

CATH Domain 5tciD02

5tciE00

CATH Domain 5tciE00

5tciF01

CATH Domain 5tciF01

5tciF02

CATH Domain 5tciF02

5tciG00

CATH Domain 5tciG00

5tciH01

CATH Domain 5tciH01

5tciH02

CATH Domain 5tciH02

PDB Prints

PDB Chains (8)

Chain ID	Date inserted into CATH	CATH Status
A	14 Nov, 2017	Chopped
B	14 Nov, 2017	Chopped
C	14 Nov, 2017	Chopped
D	14 Nov, 2017	Chopped
E	14 Nov, 2017	Chopped
F	14 Nov, 2017	Chopped
G	14 Nov, 2017	Chopped
H	14 Nov, 2017	Chopped

CATH Domains (12)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5tciA00	10 Dec, 2017	3.20.20.70	Assigned
5tciB01	10 Dec, 2017	3.40.50.1100	Assigned
5tciB02	10 Dec, 2017	3.40.50.1100	Assigned
5tciC00	10 Dec, 2017	3.20.20.70	Assigned
5tciD01	10 Dec, 2017	3.40.50.1100	Assigned
5tciD02	10 Dec, 2017	3.40.50.1100	Assigned
5tciE00	10 Dec, 2017	3.20.20.70	Assigned
5tciF01	10 Dec, 2017	3.40.50.1100	Assigned
5tciF02	10 Dec, 2017	3.40.50.1100	Assigned
5tciG00	10 Dec, 2017	3.20.20.70	Assigned
5tciH01	10 Dec, 2017	3.40.50.1100	Assigned
5tciH02	10 Dec, 2017	3.40.50.1100	Assigned

UniProtKB Entries (8)

Accession	Gene ID	Taxon	Description
P9WFY1	TRPA_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase alpha chain
P9WFY1	TRPA_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase alpha chain
P9WFX9	TRPB_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase beta chain
P9WFX9	TRPB_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase beta chain
P9WFX9	TRPB_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase beta chain
P9WFY1	TRPA_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase alpha chain
P9WFY1	TRPA_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase alpha chain
P9WFX9	TRPB_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase beta chain