PDB 5tch

PDB Links
Overview

PDB Information

PDB	5TCH
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Primary Citation	A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase. Wellington, S., Nag, P.P., Michalska, K., Johnston, S.E., Jedrzejczak, R.P., Kaushik, V.K., Clatworthy, A.E., Siddiqi, N., McCarren, P., Bajrami, B., Maltseva, N.I., Combs, S., Fisher, S.L., Joachimiak, A., Schreiber, S.L., Hung, D.T. Nat. Chem. Biol.
Header	Lyase
Released	2016-09-15
Resolution	2.350
CATH Insert Date	14 Nov, 2017

PDB Images (21)

5tch

PDB 5tch

5tchA

PDB Chain 5tchA

5tchB

PDB Chain 5tchB

5tchC

PDB Chain 5tchC

5tchD

PDB Chain 5tchD

5tchE

PDB Chain 5tchE

5tchF

PDB Chain 5tchF

5tchG

PDB Chain 5tchG

5tchH

PDB Chain 5tchH

5tchA00

CATH Domain 5tchA00

5tchB01

CATH Domain 5tchB01

5tchB02

CATH Domain 5tchB02

5tchC00

CATH Domain 5tchC00

5tchD01

CATH Domain 5tchD01

5tchD02

CATH Domain 5tchD02

5tchE00

CATH Domain 5tchE00

5tchF01

CATH Domain 5tchF01

5tchF02

CATH Domain 5tchF02

5tchG00

CATH Domain 5tchG00

5tchH01

CATH Domain 5tchH01

5tchH02

CATH Domain 5tchH02

PDB Prints

PDB Chains (8)

Chain ID	Date inserted into CATH	CATH Status
A	14 Nov, 2017	Chopped
B	14 Nov, 2017	Chopped
C	14 Nov, 2017	Chopped
D	14 Nov, 2017	Chopped
E	14 Nov, 2017	Chopped
F	14 Nov, 2017	Chopped
G	14 Nov, 2017	Chopped
H	14 Nov, 2017	Chopped

CATH Domains (12)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5tchA00	10 Dec, 2017	3.20.20.70	Assigned
5tchB01	10 Dec, 2017	3.40.50.1100	Assigned
5tchB02	10 Dec, 2017	3.40.50.1100	Assigned
5tchC00	10 Dec, 2017	3.20.20.70	Assigned
5tchD01	10 Dec, 2017	3.40.50.1100	Assigned
5tchD02	10 Dec, 2017	3.40.50.1100	Assigned
5tchE00	10 Dec, 2017	3.20.20.70	Assigned
5tchF01	10 Dec, 2017	3.40.50.1100	Assigned
5tchF02	10 Dec, 2017	3.40.50.1100	Assigned
5tchG00	10 Dec, 2017	3.20.20.70	Assigned
5tchH01	10 Dec, 2017	3.40.50.1100	Assigned
5tchH02	10 Dec, 2017	3.40.50.1100	Assigned

UniProtKB Entries (8)

Accession	Gene ID	Taxon	Description
P9WFY1	TRPA_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase alpha chain
P9WFY1	TRPA_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase alpha chain
P9WFY1	TRPA_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase alpha chain
P9WFX9	TRPB_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase beta chain
P9WFX9	TRPB_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase beta chain
P9WFX9	TRPB_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase beta chain
P9WFX9	TRPB_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase beta chain
P9WFY1	TRPA_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase alpha chain