PDB 5tcf

PDB Links
Overview

PDB Information

PDB	5TCF
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Primary Citation	A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase. Wellington, S., Nag, P.P., Michalska, K., Johnston, S.E., Jedrzejczak, R.P., Kaushik, V.K., Clatworthy, A.E., Siddiqi, N., McCarren, P., Bajrami, B., Maltseva, N.I., Combs, S., Fisher, S.L., Joachimiak, A., Schreiber, S.L., Hung, D.T. Nat. Chem. Biol.
Header	Lyase
Released	2016-09-15
Resolution	2.460
CATH Insert Date	14 Nov, 2017

PDB Images (21)

5tcf

PDB 5tcf

5tcfA

PDB Chain 5tcfA

5tcfB

PDB Chain 5tcfB

5tcfC

PDB Chain 5tcfC

5tcfD

PDB Chain 5tcfD

5tcfE

PDB Chain 5tcfE

5tcfF

PDB Chain 5tcfF

5tcfG

PDB Chain 5tcfG

5tcfH

PDB Chain 5tcfH

5tcfA00

CATH Domain 5tcfA00

5tcfB01

CATH Domain 5tcfB01

5tcfB02

CATH Domain 5tcfB02

5tcfC00

CATH Domain 5tcfC00

5tcfD01

CATH Domain 5tcfD01

5tcfD02

CATH Domain 5tcfD02

5tcfE00

CATH Domain 5tcfE00

5tcfF01

CATH Domain 5tcfF01

5tcfF02

CATH Domain 5tcfF02

5tcfG00

CATH Domain 5tcfG00

5tcfH01

CATH Domain 5tcfH01

5tcfH02

CATH Domain 5tcfH02

PDB Prints

PDB Chains (8)

Chain ID	Date inserted into CATH	CATH Status
A	14 Nov, 2017	Chopped
B	14 Nov, 2017	Chopped
C	14 Nov, 2017	Chopped
D	14 Nov, 2017	Chopped
E	14 Nov, 2017	Chopped
F	14 Nov, 2017	Chopped
G	14 Nov, 2017	Chopped
H	14 Nov, 2017	Chopped

CATH Domains (12)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5tcfA00	10 Dec, 2017	3.20.20.70	Assigned
5tcfB01	10 Dec, 2017	3.40.50.1100	Assigned
5tcfB02	10 Dec, 2017	3.40.50.1100	Assigned
5tcfC00	10 Dec, 2017	3.20.20.70	Assigned
5tcfD01	10 Dec, 2017	3.40.50.1100	Assigned
5tcfD02	10 Dec, 2017	3.40.50.1100	Assigned
5tcfE00	10 Dec, 2017	3.20.20.70	Assigned
5tcfF01	10 Dec, 2017	3.40.50.1100	Assigned
5tcfF02	10 Dec, 2017	3.40.50.1100	Assigned
5tcfG00	10 Dec, 2017	3.20.20.70	Assigned
5tcfH01	10 Dec, 2017	3.40.50.1100	Assigned
5tcfH02	10 Dec, 2017	3.40.50.1100	Assigned

UniProtKB Entries (8)

Accession	Gene ID	Taxon	Description
P9WFY1	TRPA_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase alpha chain
P9WFY1	TRPA_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase alpha chain
P9WFX9	TRPB_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase beta chain
P9WFY1	TRPA_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase alpha chain
P9WFY1	TRPA_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase alpha chain
P9WFX9	TRPB_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase beta chain
P9WFX9	TRPB_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase beta chain
P9WFX9	TRPB_MYCTU	Mycobacterium tuberculosis H37Rv	Tryptophan synthase beta chain