PDB 5t1t

PDB Information

PDB5T1T
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation.
Smith, G.F., Altman, M.D., Andresen, B., Baker, J., Brubaker, J.D., Chen, H., Chen, Y., Childers, M., Donofrio, A., Ferguson, H., Fischer, C., Fischmann, T.O., Gibeau, C., Hicks, A., Jin, S., Kattar, S., Kleinschek, M.A., Leccese, E., Lesburg, C., Li, C., Lim, J., Liu, D., Maclean, J.K.F., Mansoor, F., Moy, L.Y., Mulrooney, E.F., Necheva, A.S., Presland, J., Rakhilina, L., Yang, R., Torres, L., Zhang-Hoover, J., Northrup, A.
Bioorg. Med. Chem. Lett.
HeaderTransferase/Transferase Inhibitor
Released2016-08-22
Resolution2.340
CATH Insert Date14 May, 2017

PDB Images (13)

PDB Prints

PDB Chains (4)

Chain ID Date inserted into CATH CATH Status
A 15 May, 2017 Chopped
B 15 May, 2017 Chopped
C 15 May, 2017 Chopped
D 15 May, 2017 Chopped

CATH Domains (8)

Domain ID Date inserted into CATH Superfamily CATH Status
5t1tA01 12 Jul, 2018 3.30.200.20 Assigned
5t1tA02 12 Jul, 2018 1.10.510.10 Assigned
5t1tB01 12 Jul, 2018 3.30.200.20 Assigned
5t1tB02 12 Jul, 2018 1.10.510.10 Assigned
5t1tC01 12 Jul, 2018 3.30.200.20 Assigned
5t1tC02 12 Jul, 2018 1.10.510.10 Assigned
5t1tD01 12 Jul, 2018 3.30.200.20 Assigned
5t1tD02 12 Jul, 2018 1.10.510.10 Assigned

UniProtKB Entries (4)

Accession Gene ID Taxon Description
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4
Q9NWZ3 IRAK4_HUMAN Homo sapiens Interleukin-1 receptor-associated kinase 4