Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers.
Watterson, S.H., De Lucca, G.V., Shi, Q., Langevine, C.M., Liu, Q., Batt, D.G., Beaudoin Bertrand, M., Gong, H., Dai, J., Yip, S., Li, P., Sun, D., Wu, D.R., Wang, C., Zhang, Y., Traeger, S.C., Pattoli, M.A., Skala, S., Cheng, L., Obermeier, M.T., Vickery, R., Discenza, L.N., D'Arienzo, C.J., Zhang, Y., Heimrich, E., Gillooly, K.M., Taylor, T.L., Pulicicchio, C., McIntyre, K.W., Galella, M.A., Tebben, A.J., Muckelbauer, J.K., Chang, C., Rampulla, R., Mathur, A., Salter-Cid, L., Barrish, J.C., Carter, P.H., Fura, A., Burke, J.R., Tino, J.A.
J. Med. Chem.