PDB 5nw1

PDB Information

PDB5NW1
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298).
Soares, P., Gadd, M.S., Frost, J., Galdeano, C., Ellis, L., Epemolu, O., Rocha, S., Read, K.D., Ciulli, A.
J. Med. Chem.
HeaderLigase
Released2017-05-04
Resolution2.100
CATH Insert Date14 Nov, 2017

PDB Images (29)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped
C 14 Nov, 2017 Chopped
D 14 Nov, 2017 Chopped
E 14 Nov, 2017 Chopped
F 14 Nov, 2017 Chopped
G 14 Nov, 2017 Chopped
H 14 Nov, 2017 Chopped
I 14 Nov, 2017 Chopped
J 14 Nov, 2017 Chopped
K 14 Nov, 2017 Chopped
L 14 Nov, 2017 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
5nw1A00 10 Dec, 2017 3.10.20.90 Assigned
5nw1B00 10 Dec, 2017 3.30.710.10 Assigned
5nw1C01 10 Dec, 2017 2.60.40.780 Assigned
5nw1C02 10 Dec, 2017 1.10.750.10 Assigned
5nw1D00 10 Dec, 2017 3.10.20.90 Assigned
5nw1E00 10 Dec, 2017 3.30.710.10 Assigned
5nw1F01 10 Dec, 2017 2.60.40.780 Assigned
5nw1F02 10 Dec, 2017 1.10.750.10 Assigned
5nw1G00 10 Dec, 2017 3.10.20.90 Assigned
5nw1H00 10 Dec, 2017 3.30.710.10 Assigned
5nw1I01 10 Dec, 2017 2.60.40.780 Assigned
5nw1I02 10 Dec, 2017 1.10.750.10 Assigned
5nw1J00 10 Dec, 2017 3.10.20.90 Assigned
5nw1K00 10 Dec, 2017 3.30.710.10 Assigned
5nw1L01 10 Dec, 2017 2.60.40.780 Assigned
5nw1L02 10 Dec, 2017 1.10.750.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor