PDB 5m7e

PDB Information

PDB5M7E
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceRattus norvegicus
Primary Citation
Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Bohnacker, T., Prota, A.E., Beaufils, F., Burke, J.E., Melone, A., Inglis, A.J., Rageot, D., Sele, A.M., Cmiljanovic, V., Cmiljanovic, N., Bargsten, K., Aher, A., Akhmanova, A., Diaz, J.F., Fabbro, D., Zvelebil, M., Williams, R.L., Steinmetz, M.O., Wymann, M.P.
Nat Commun
HeaderCell Cycle
Released2016-10-27
Resolution2.050
CATH Insert Date07 May, 2017

PDB Images (23)

PDB Prints

PDB Chains (6)

Chain ID Date inserted into CATH CATH Status
A 08 May, 2017 Chopped
B 08 May, 2017 Chopped
C 08 May, 2017 Chopped
D 08 May, 2017 Chopped
E 08 May, 2017 Chopped
F 08 May, 2017 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
5m7eA01 16 May, 2017 3.40.50.1440 Assigned
5m7eA02 16 May, 2017 3.30.1330.20 Assigned
5m7eA03 16 May, 2017 1.10.287.600 Assigned
5m7eB01 16 May, 2017 3.40.50.1440 Assigned
5m7eB02 16 May, 2017 3.30.1330.20 Assigned
5m7eB03 16 May, 2017 1.10.287.600 Assigned
5m7eC01 16 May, 2017 3.40.50.1440 Assigned
5m7eC02 16 May, 2017 3.30.1330.20 Assigned
5m7eC03 16 May, 2017 1.10.287.600 Assigned
5m7eD01 16 May, 2017 3.40.50.1440 Assigned
5m7eD02 16 May, 2017 3.30.1330.20 Assigned
5m7eD03 16 May, 2017 1.10.287.600 Assigned
5m7eE01 15 May, 2017 6.10.280.30 Assigned
5m7eF01 16 May, 2017 3.40.50.11480 Assigned
5m7eF02 16 May, 2017 3.30.470.20 Assigned
5m7eF03 16 May, 2017 3.30.1490.20 Assigned

UniProtKB Entries (6)

Accession Gene ID Taxon Description
P81947 TBA1B_BOVIN Bos taurus Tubulin alpha-1B chain
P81947 TBA1B_BOVIN Bos taurus Tubulin alpha-1B chain
Q6B856 TBB2B_BOVIN Bos taurus Tubulin beta-2B chain
P63043 STMN4_RAT Rattus norvegicus Stathmin-4
Q6B856 TBB2B_BOVIN Bos taurus Tubulin beta-2B chain
E1BQ43 E1BQ43_CHICK Gallus gallus Uncharacterized protein