PDB 5m2i

PDB Information

PDB5M2I
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli BL21
Gene SourceHomo sapiens
Primary Citation
Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions.
Beirnaert, E., Desmyter, A., Spinelli, S., Lauwereys, M., Aarden, L., Dreier, T., Loris, R., Silence, K., Pollet, C., Cambillau, C., de Haard, H.
Front Immunol
HeaderCytokine
Released2016-10-13
Resolution2.150
CATH Insert Date14 Nov, 2017

PDB Images (25)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped
C 14 Nov, 2017 Chopped
D 14 Nov, 2017 Chopped
E 14 Nov, 2017 Chopped
F 14 Nov, 2017 Chopped
G 14 Nov, 2017 Chopped
H 14 Nov, 2017 Chopped
I 14 Nov, 2017 Chopped
J 14 Nov, 2017 Chopped
K 14 Nov, 2017 Chopped
L 14 Nov, 2017 Chopped

CATH Domains (12)

Domain ID Date inserted into CATH Superfamily CATH Status
5m2iA00 10 Dec, 2017 2.60.120.40 Assigned
5m2iB00 10 Dec, 2017 2.60.120.40 Assigned
5m2iC00 10 Dec, 2017 2.60.120.40 Assigned
5m2iD00 10 Dec, 2017 2.60.120.40 Assigned
5m2iE00 10 Dec, 2017 2.60.120.40 Assigned
5m2iF00 10 Dec, 2017 2.60.120.40 Assigned
5m2iG00 10 Dec, 2017 2.60.40.10 Assigned
5m2iH00 10 Dec, 2017 2.60.40.10 Assigned
5m2iI00 10 Dec, 2017 2.60.40.10 Assigned
5m2iJ00 10 Dec, 2017 2.60.40.10 Assigned
5m2iK00 10 Dec, 2017 2.60.40.10 Assigned
5m2iL00 10 Dec, 2017 2.60.40.10 Assigned

UniProtKB Entries (6)

Accession Gene ID Taxon Description
P01375 TNFA_HUMAN Homo sapiens Tumor necrosis factor
P01375 TNFA_HUMAN Homo sapiens Tumor necrosis factor
P01375 TNFA_HUMAN Homo sapiens Tumor necrosis factor
P01375 TNFA_HUMAN Homo sapiens Tumor necrosis factor
P01375 TNFA_HUMAN Homo sapiens Tumor necrosis factor
P01375 TNFA_HUMAN Homo sapiens Tumor necrosis factor