PDB 5lge

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Overview

PDB Information

PDB	5LGE
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo. Pusch, S., Krausert, S., Fischer, V., Balss, J., Ott, M., Schrimpf, D., Capper, D., Sahm, F., Eisel, J., Beck, A.C., Jugold, M., Eichwald, V., Kaulfuss, S., Panknin, O., Rehwinkel, H., Zimmermann, K., Hillig, R.C., Guenther, J., Toschi, L., Neuhaus, R., Haegebart, A., Hess-Stumpp, H., Bauser, M., Wick, W., Unterberg, A., Herold-Mende, C., Platten, M., von Deimling, A. Acta Neuropathol.
Header	Oxidoreductase
Released	2016-07-07
Resolution	2.700
CATH Insert Date	07 May, 2017

PDB Images (9)

Image of CATH 5lge

5lge

PDB 5lge

Image of CATH 5lgeA

5lgeA

PDB Chain 5lgeA

Image of CATH 5lgeB

5lgeB

PDB Chain 5lgeB

Image of CATH 5lgeC

5lgeC

PDB Chain 5lgeC

Image of CATH 5lgeD

5lgeD

PDB Chain 5lgeD

Image of CATH 5lgeA00

5lgeA00

CATH Domain 5lgeA00

Image of CATH 5lgeB00

5lgeB00

CATH Domain 5lgeB00

Image of CATH 5lgeC00

5lgeC00

CATH Domain 5lgeC00

Image of CATH 5lgeD00

5lgeD00

CATH Domain 5lgeD00

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	08 May, 2017	Chopped
B	08 May, 2017	Chopped
C	08 May, 2017	Chopped
D	08 May, 2017	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5lgeA00	14 May, 2017	3.40.718.10	Assigned
5lgeB00	14 May, 2017	3.40.718.10	Assigned
5lgeC00	14 May, 2017	3.40.718.10	Assigned
5lgeD00	14 May, 2017	3.40.718.10	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
O75874	IDHC_HUMAN	Homo sapiens	Isocitrate dehydrogenase [NADP] cytoplasmic
O75874	IDHC_HUMAN	Homo sapiens	Isocitrate dehydrogenase [NADP] cytoplasmic
O75874	IDHC_HUMAN	Homo sapiens	Isocitrate dehydrogenase [NADP] cytoplasmic
O75874	IDHC_HUMAN	Homo sapiens	Isocitrate dehydrogenase [NADP] cytoplasmic