PDB 5lbo

PDB Links
Overview

PDB Information

PDB	5LBO
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli BL21(DE3)
Gene Source	Homo sapiens
Primary Citation	Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity. Blaazer, A.R., Singh, A.K., de Heuvel, E., Edink, E., Orrling, K.M., Veerman, J.J.N., van den Bergh, T., Jansen, C., Balasubramaniam, E., Mooij, W.J., Custers, H., Sijm, M., Tagoe, D.N.A., Kalejaiye, T.D., Munday, J.C., Tenor, H., Matheeussen, A., Wijtmans, M., Siderius, M., de Graaf, C., Maes, L., de Koning, H.P., Bailey, D.S., Sterk, G.J., de Esch, I.J.P., Brown, D.G., Leurs, R. J. Med. Chem.
Header	Hydrolase
Released	2016-06-16
Resolution	2.250
CATH Insert Date	03 Jun, 2018

PDB Images (9)

Image of CATH 5lbo

5lbo

PDB 5lbo

Image of CATH 5lboA

5lboA

PDB Chain 5lboA

Image of CATH 5lboB

5lboB

PDB Chain 5lboB

Image of CATH 5lboC

5lboC

PDB Chain 5lboC

Image of CATH 5lboD

5lboD

PDB Chain 5lboD

Image of CATH 5lboA00

5lboA00

CATH Domain 5lboA00

Image of CATH 5lboB00

5lboB00

CATH Domain 5lboB00

Image of CATH 5lboC00

5lboC00

CATH Domain 5lboC00

Image of CATH 5lboD00

5lboD00

CATH Domain 5lboD00

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	03 Jun, 2018	Chopped
B	03 Jun, 2018	Chopped
C	03 Jun, 2018	Chopped
D	03 Jun, 2018	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5lboA00	27 Jun, 2018	1.10.1300.10	Assigned
5lboB00	27 Jun, 2018	1.10.1300.10	Assigned
5lboC00	27 Jun, 2018	1.10.1300.10	Assigned
5lboD00	27 Jun, 2018	1.10.1300.10	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
Q08499	PDE4D_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Q08499	PDE4D_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Q08499	PDE4D_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Q08499	PDE4D_HUMAN	Homo sapiens	cAMP-specific 3',5'-cyclic phosphodiesterase 4D