PDB Information

PDB5KZQ
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.
Chappell, M.D., Li, R., Smith, S.C., Dressman, B.A., Tromiczak, E.G., Tripp, A.E., Blanco, M.J., Vetman, T., Quimby, S.J., Matt, J., Britton, T.C., Fivush, A.M., Schkeryantz, J.M., Mayhugh, D., Erickson, J.A., Bures, M.G., Jaramillo, C., Carpintero, M., Diego, J.E., Barberis, M., Garcia-Cerrada, S., Soriano, J.F., Antonysamy, S., Atwell, S., MacEwan, I., Condon, B., Sougias, C., Wang, J., Zhang, A., Conners, K., Groshong, C., Wasserman, S.R., Koss, J.W., Witkin, J.M., Li, X., Overshiner, C., Wafford, K.A., Seidel, W., Wang, X.S., Heinz, B.A., Swanson, S., Catlow, J.T., Bedwell, D.W., Monn, J.A., Mitch, C.H., Ornstein, P.L.
J. Med. Chem.
HeaderSignaling Protein
Released2016-07-25
Resolution2.800
CATH Insert Date08 Jan, 2017

PDB Images (2)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 09 Jan, 2017 Holding pen

CATH Domains (0)

Domain ID Date inserted into CATH Superfamily CATH Status

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q14416 GRM2_HUMAN Homo sapiens Metabotropic glutamate receptor 2