PDB Information

PDB5KQ5
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceRattus norvegicus
Primary Citation
Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.
Cameron, K.O., Kung, D.W., Kalgutkar, A.S., Kurumbail, R.G., Miller, R., Salatto, C.T., Ward, J., Withka, J.M., Bhattacharya, S.K., Boehm, M., Borzilleri, K.A., Brown, J.A., Calabrese, M., Caspers, N.L., Cokorinos, E., Conn, E.L., Dowling, M.S., Edmonds, D.J., Eng, H., Fernando, D.P., Frisbie, R., Hepworth, D., Landro, J., Mao, Y., Rajamohan, F., Reyes, A.R., Rose, C.R., Ryder, T., Shavnya, A., Smith, A.C., Tu, M., Wolford, A.C., Xiao, J.
J.Med.Chem.
HeaderTransferase
Released2016-07-05
Resolution3.410
CATH Insert Date04 Sep, 2016

PDB Images (4)

PDB Prints

PDB Chains (3)

Chain ID Date inserted into CATH CATH Status
A 05 Sep, 2016 Holding pen
B 05 Sep, 2016 Holding pen
C 05 Sep, 2016 Holding pen

CATH Domains (0)

Domain ID Date inserted into CATH Superfamily CATH Status

UniProtKB Entries (3)

Accession Gene ID Taxon Description
P54645 AAPK1_RAT Rattus norvegicus 5'-AMP-activated protein kinase catalytic subunit alpha-1
P80386 AAKB1_RAT Rattus norvegicus 5'-AMP-activated protein kinase subunit beta-1
P80385 AAKG1_RAT Rattus norvegicus 5'-AMP-activated protein kinase subunit gamma-1