PDB 5kcv

PDB Information

PDB5KCV
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor.
Lapierre, J.M., Eathiraj, S., Vensel, D., Liu, Y., Bull, C.O., Cornell-Kennon, S., Iimura, S., Kelleher, E.W., Kizer, D.E., Koerner, S., Makhija, S., Matsuda, A., Moussa, M., Namdev, N., Savage, R.E., Szwaya, J., Volckova, E., Westlund, N., Wu, H., Schwartz, B.
J.Med.Chem.
HeaderTransferase/Inhibitor
Released2016-06-07
Resolution2.700
CATH Insert Date10 Jul, 2016

PDB Images (5)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 11 Jul, 2016 Chopped

CATH Domains (3)

Domain ID Date inserted into CATH Superfamily CATH Status
5kcvA01 20 Jul, 2016 2.30.29.30 Assigned
5kcvA02 20 Jul, 2016 3.30.200.20 Assigned
5kcvA03 20 Jul, 2016 1.10.510.10 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
P31749 AKT1_HUMAN Homo sapiens RAC-alpha serine/threonine-protein kinase