PDB 5iwm

PDB Links
Overview

PDB Information

PDB	5IWM
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Staphylococcus aureus
Primary Citation	Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases. Miles, T.J., Hennessy, A.J., Bax, B., Brooks, G., Brown, B.S., Brown, P., Cailleau, N., Chen, D., Dabbs, S., Davies, D.T., Esken, J.M., Giordano, I., Hoover, J.L., Jones, G.E., Kusalakumari Sukmar, S.K., Markwell, R.E., Minthorn, E.A., Rittenhouse, S., Gwynn, M.N., Pearson, N.D. Bioorg.Med.Chem.Lett.
Header	Isomerase
Released	2016-03-22
Resolution	2.500
CATH Insert Date	10 Jul, 2016

PDB Images (11)

Image of CATH 5iwm

5iwm

PDB 5iwm

Image of CATH 5iwmA

5iwmA

PDB Chain 5iwmA

Image of CATH 5iwmB

5iwmB

PDB Chain 5iwmB

Image of CATH 5iwmC

5iwmC

PDB Chain 5iwmC

Image of CATH 5iwmD

5iwmD

PDB Chain 5iwmD

Image of CATH 5iwmE

5iwmE

PDB Chain 5iwmE

Image of CATH 5iwmF

5iwmF

PDB Chain 5iwmF

Image of CATH 5iwmA00

5iwmA00

CATH Domain 5iwmA00

Image of CATH 5iwmB01

5iwmB01

CATH Domain 5iwmB01

Image of CATH 5iwmC00

5iwmC00

CATH Domain 5iwmC00

Image of CATH 5iwmD01

5iwmD01

CATH Domain 5iwmD01

PDB Prints

PDB Chains (6)

Chain ID	Date inserted into CATH	CATH Status
A	11 Jul, 2016	Chopped
B	11 Jul, 2016	Chopped
C	11 Jul, 2016	Chopped
D	11 Jul, 2016	Chopped
E	11 Jul, 2016	Rejected
F	11 Jul, 2016	Rejected

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5iwmA00	18 Jul, 2016		Holding pen
5iwmB01	23 Jan, 2017		Holding pen
5iwmC00	19 Jul, 2016		Holding pen
5iwmD01	23 Jan, 2017		Holding pen

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
P66937	GYRB_STAAN	Staphylococcus aureus subsp. aureus N315	DNA gyrase subunit B
Q99XG5	GYRA_STAAN	Staphylococcus aureus subsp. aureus N315	DNA gyrase subunit A
Q99XG5	GYRA_STAAN	Staphylococcus aureus subsp. aureus N315	DNA gyrase subunit A
P66937	GYRB_STAAN	Staphylococcus aureus subsp. aureus N315	DNA gyrase subunit B