PDB 5iwi

PDB Information

PDB5IWI
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceStaphylococcus aureus
Primary Citation
Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases.
Miles, T.J., Hennessy, A.J., Bax, B., Brooks, G., Brown, B.S., Brown, P., Cailleau, N., Chen, D., Dabbs, S., Davies, D.T., Esken, J.M., Giordano, I., Hoover, J.L., Jones, G.E., Kusalakumari Sukmar, S.K., Markwell, R.E., Minthorn, E.A., Rittenhouse, S., Gwynn, M.N., Pearson, N.D.
Bioorg.Med.Chem.Lett.
HeaderIsomerase
Released2016-03-22
Resolution1.980
CATH Insert Date05 Jun, 2016

PDB Images (12)

PDB Prints

PDB Chains (7)

Chain ID Date inserted into CATH CATH Status
A 06 Jun, 2016 Chopped
B 06 Jun, 2016 Chopped
C 06 Jun, 2016 Chopped
D 06 Jun, 2016 Chopped
E 06 Jun, 2016 Rejected
F 06 Jun, 2016 Rejected
G 06 Jun, 2016 Rejected

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
5iwiA00 19 Jul, 2016 Holding pen
5iwiB01 23 Jan, 2017 Holding pen
5iwiC00 19 Jul, 2016 Holding pen
5iwiD01 23 Jan, 2017 Holding pen

UniProtKB Entries (4)

Accession Gene ID Taxon Description
Q99XG5 GYRA_STAAN Staphylococcus aureus subsp. aureus N315 DNA gyrase subunit A
P66937 GYRB_STAAN Staphylococcus aureus subsp. aureus N315 DNA gyrase subunit B
Q99XG5 GYRA_STAAN Staphylococcus aureus subsp. aureus N315 DNA gyrase subunit A
P66937 GYRB_STAAN Staphylococcus aureus subsp. aureus N315 DNA gyrase subunit B