PDB 5ime

PDB Information

PDB5IME
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window.
Rudolph, J., Murray, L.J., Ndubaku, C.O., O'Brien, T., Blackwood, E., Wang, W., Aliagas, I., Gazzard, L., Crawford, J.J., Drobnick, J., Lee, W., Zhao, X., Hoeflich, K.P., Favor, D.A., Dong, P., Zhang, H., Heise, C.E., Oh, A., Ong, C.C., La, H., Chakravarty, P., Chan, C., Jakubiak, D., Epler, J., Ramaswamy, S., Vega, R., Cain, G., Diaz, D., Zhong, Y.
J.Med.Chem.
HeaderTransferase/Transferase Inhibitor
Released2016-03-06
Resolution2.220
CATH Insert Date05 Jun, 2016

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 06 Jun, 2016 Chopped
B 06 Jun, 2016 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
5imeA01 18 Jul, 2016 3.30.200.20 Assigned
5imeA02 18 Jul, 2016 1.10.510.10 Assigned
5imeB01 18 Jul, 2016 3.30.200.20 Assigned
5imeB02 18 Jul, 2016 1.10.510.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q13153 PAK1_HUMAN Homo sapiens Serine/threonine-protein kinase PAK 1
Q13153 PAK1_HUMAN Homo sapiens Serine/threonine-protein kinase PAK 1