PDB 5i86

PDB Information

PDB5I86
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).
Taylor, A.M., Cote, A., Hewitt, M.C., Pastor, R., Leblanc, Y., Nasveschuk, C.G., Romero, F.A., Crawford, T.D., Cantone, N., Jayaram, H., Setser, J., Murray, J., Beresini, M.H., de Leon Boenig, G., Chen, Z., Conery, A.R., Cummings, R.T., Dakin, L.A., Flynn, E.M., Huang, O.W., Kaufman, S., Keller, P.J., Kiefer, J.R., Lai, T., Li, Y., Liao, J., Liu, W., Lu, H., Pardo, E., Tsui, V., Wang, J., Wang, Y., Xu, Z., Yan, F., Yu, D., Zawadzke, L., Zhu, X., Zhu, X., Sims, R.J., Cochran, A.G., Bellon, S., Audia, J.E., Magnuson, S., Albrecht, B.K.
Acs Med.Chem.Lett.
HeaderProtein Binding/Inhibitor
Released2016-02-18
Resolution1.050
CATH Insert Date24 Apr, 2016

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 25 Apr, 2016 Chopped
B 25 Apr, 2016 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
5i86A00 15 May, 2016 1.20.920.10 Assigned
5i86B00 15 May, 2016 1.20.920.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q92793 CBP_HUMAN Homo sapiens CREB-binding protein
Q92793 CBP_HUMAN Homo sapiens CREB-binding protein