Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease.
Scott, J.D., Li, S.W., Brunskill, A.P., Chen, X., Cox, K., Cumming, J.N., Forman, M., Gilbert, E.J., Hodgson, R.A., Hyde, L.A., Jiang, Q., Iserloh, U., Kazakevich, I., Kuvelkar, R., Mei, H., Meredith, J., Misiaszek, J., Orth, P., Rossiter, L.M., Slater, M., Stone, J., Strickland, C.O., Voigt, J.H., Wang, G., Wang, H., Wu, Y., Greenlee, W.J., Parker, E.M., Kennedy, M.E., Stamford, A.W.
J. Med. Chem.