PDB 5h24

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Overview

PDB Information

PDB	5H24
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy Huang, Y., Zhang, J., Yu, Z., Zhang, H., Wang, Y., Lingel, A., Qi, W., Gu, J., Zhao, K., Shultz, M.D., Wang, L., Fu, X., Sun, Y., Zhang, Q., Jiang, X., Zhang, J., Zhang, C., Li, L., Zeng, J., Feng, L., Zhang, C., Liu, Y., Zhang, M., Zhang, L., Zhao, M., Gao, Z., Liu, X., Fang, D., Guo, H., Mi, Y., Gabriel, T., Dillon, M.P., Atadja, P., Oyang, C. J. Med. Chem.
Header	Transferase/Transferase Inhibitor
Released	2016-10-14
Resolution	2.500
CATH Insert Date	07 May, 2017

PDB Images (7)

Image of CATH 5h24

5h24

PDB 5h24

Image of CATH 5h24A

5h24A

PDB Chain 5h24A

Image of CATH 5h24B

5h24B

PDB Chain 5h24B

Image of CATH 5h24C

5h24C

PDB Chain 5h24C

Image of CATH 5h24D

5h24D

PDB Chain 5h24D

Image of CATH 5h24A00

5h24A00

CATH Domain 5h24A00

Image of CATH 5h24B00

5h24B00

CATH Domain 5h24B00

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	08 May, 2017	Chopped
B	08 May, 2017	Chopped
C	08 May, 2017	Rejected
D	08 May, 2017	Rejected

CATH Domains (2)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5h24A00	14 Dec, 2017	2.130.10.10	Assigned
5h24B00	14 Dec, 2017	2.130.10.10	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
Q15910	EZH2_HUMAN	Homo sapiens	Histone-lysine N-methyltransferase EZH2
O75530	EED_HUMAN	Homo sapiens	Polycomb protein EED
O75530	EED_HUMAN	Homo sapiens	Polycomb protein EED
Q15910	EZH2_HUMAN	Homo sapiens	Histone-lysine N-methyltransferase EZH2