PDB Information

PDB5EHR
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.
Chen, Y.P., LaMarche, M.J., Chan, H.M., Fekkes, P., Garcia-Fortanet, J., Acker, M.G., Antonakos, B., Chen, C.H., Chen, Z., Cooke, V.G., Dobson, J.R., Deng, Z., Fei, F., Firestone, B., Fodor, M., Fridrich, C., Gao, H., Grunenfelder, D., Hao, H.X., Jacob, J., Ho, S., Hsiao, K., Kang, Z.B., Karki, R., Kato, M., Larrow, J., La Bonte, L.R., Lenoir, F., Liu, G., Liu, S., Majumdar, D., Meyer, M.J., Palermo, M., Perez, L., Pu, M., Price, E., Quinn, C., Shakya, S., Shultz, M.D., Slisz, J., Venkatesan, K., Wang, P., Warmuth, M., Williams, S., Yang, G., Yuan, J., Zhang, J.H., Zhu, P., Ramsey, T., Keen, N.J., Sellers, W.R., Stams, T., Fortin, P.D.
Nature
HeaderHydrolase/Hydrolase Inhibitor
Released2015-10-28
Resolution1.700
CATH Insert Date10 Jul, 2016

PDB Images (9)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 11 Jul, 2016 Chopped
B 11 Jul, 2016 Chopped

CATH Domains (6)

Domain ID Date inserted into CATH Superfamily CATH Status
5ehrA01 14 Jul, 2016 3.30.505.10 Assigned
5ehrA02 14 Jul, 2016 3.30.505.10 Assigned
5ehrA03 14 Jul, 2016 3.90.190.10 Assigned
5ehrB01 14 Jul, 2016 3.30.505.10 Assigned
5ehrB02 14 Jul, 2016 3.30.505.10 Assigned
5ehrB03 14 Jul, 2016 3.90.190.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q06124 PTN11_HUMAN Homo sapiens Tyrosine-protein phosphatase non-receptor type 11
Q06124 PTN11_HUMAN Homo sapiens Tyrosine-protein phosphatase non-receptor type 11