PDB Information

PDB5EHP
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.
Garcia Fortanet, J., Chen, C.H., Chen, Y.N., Chen, Z., Deng, Z., Firestone, B., Fekkes, P., Fodor, M., Fortin, P.D., Fridrich, C., Grunenfelder, D., Ho, S., Kang, Z.B., Karki, R., Kato, M., Keen, N., LaBonte, L.R., Larrow, J., Lenoir, F., Liu, G., Liu, S., Lombardo, F., Majumdar, D., Meyer, M.J., Palermo, M., Perez, L., Pu, M., Ramsey, T., Sellers, W.R., Shultz, M.D., Stams, T., Towler, C., Wang, P., Williams, S.L., Zhang, J.H., LaMarche, M.J.
J.Med.Chem.
HeaderHydrolase/Hydrolase Inhibitor
Released2015-10-28
Resolution1.850
CATH Insert Date17 Jul, 2016

PDB Images (9)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 18 Jul, 2016 Chopped
B 18 Jul, 2016 Chopped

CATH Domains (6)

Domain ID Date inserted into CATH Superfamily CATH Status
5ehpA01 01 Sep, 2016 3.30.505.10 Assigned
5ehpA02 01 Sep, 2016 3.30.505.10 Assigned
5ehpA03 01 Sep, 2016 3.90.190.10 Assigned
5ehpB01 01 Sep, 2016 3.30.505.10 Assigned
5ehpB02 01 Sep, 2016 3.30.505.10 Assigned
5ehpB03 01 Sep, 2016 3.90.190.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q06124 PTN11_HUMAN Homo sapiens Tyrosine-protein phosphatase non-receptor type 11
Q06124 PTN11_HUMAN Homo sapiens Tyrosine-protein phosphatase non-receptor type 11
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