PDB 5ece

PDB Links
Overview

PDB Information

PDB	5ECE
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering. Johannes, J.W., Almeida, L., Daly, K., Ferguson, A.D., Grosskurth, S.E., Guan, H., Howard, T., Ioannidis, S., Kazmirski, S., Lamb, M.L., Larsen, N.A., Lyne, P.D., Mikule, K., Ogoe, C., Peng, B., Petteruti, P., Read, J.A., Su, N., Sylvester, M., Throner, S., Wang, W., Wang, X., Wu, J., Ye, Q., Yu, Y., Zheng, X., Scott, D.A. Bioorg.Med.Chem.Lett.
Header	Transferase/Transferase Inhibitor
Released	2015-10-20
Resolution	2.200
CATH Insert Date	06 Dec, 2015

PDB Images (9)

Image of CATH 5ece

5ece

PDB 5ece

Image of CATH 5eceA

5eceA

PDB Chain 5eceA

Image of CATH 5eceB

5eceB

PDB Chain 5eceB

Image of CATH 5eceC

5eceC

PDB Chain 5eceC

Image of CATH 5eceD

5eceD

PDB Chain 5eceD

Image of CATH 5eceA00

5eceA00

CATH Domain 5eceA00

Image of CATH 5eceB00

5eceB00

CATH Domain 5eceB00

Image of CATH 5eceC00

5eceC00

CATH Domain 5eceC00

Image of CATH 5eceD00

5eceD00

CATH Domain 5eceD00

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	07 Dec, 2015	Chopped
B	07 Dec, 2015	Chopped
C	07 Dec, 2015	Chopped
D	07 Dec, 2015	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5eceA00	09 Dec, 2015	3.90.228.10	Assigned
5eceB00	05 Jan, 2016	3.90.228.10	Assigned
5eceC00	05 Jan, 2016	3.90.228.10	Assigned
5eceD00	05 Jan, 2016	3.90.228.10	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
O95271	TNKS1_HUMAN	Homo sapiens	Poly [ADP-ribose] polymerase tankyrase-1
O95271	TNKS1_HUMAN	Homo sapiens	Poly [ADP-ribose] polymerase tankyrase-1
O95271	TNKS1_HUMAN	Homo sapiens	Poly [ADP-ribose] polymerase tankyrase-1
O95271	TNKS1_HUMAN	Homo sapiens	Poly [ADP-ribose] polymerase tankyrase-1