PDB 5ebt

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PDB Links
Overview

PDB Information

PDB	5EBT
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering. Johannes, J.W., Almeida, L., Daly, K., Ferguson, A.D., Grosskurth, S.E., Guan, H., Howard, T., Ioannidis, S., Kazmirski, S., Lamb, M.L., Larsen, N.A., Lyne, P.D., Mikule, K., Ogoe, C., Peng, B., Petteruti, P., Read, J.A., Su, N., Sylvester, M., Throner, S., Wang, W., Wang, X., Wu, J., Ye, Q., Yu, Y., Zheng, X., Scott, D.A. Bioorg.Med.Chem.Lett.
Header	Transferase/Transferase Inhibitor
Released	2015-10-19
Resolution	2.240
CATH Insert Date	10 Apr, 2016

PDB Images (9)

Image of CATH 5ebt

5ebt

PDB 5ebt

Image of CATH 5ebtA

5ebtA

PDB Chain 5ebtA

Image of CATH 5ebtB

5ebtB

PDB Chain 5ebtB

Image of CATH 5ebtC

5ebtC

PDB Chain 5ebtC

Image of CATH 5ebtD

5ebtD

PDB Chain 5ebtD

Image of CATH 5ebtA00

5ebtA00

CATH Domain 5ebtA00

Image of CATH 5ebtB00

5ebtB00

CATH Domain 5ebtB00

Image of CATH 5ebtC00

5ebtC00

CATH Domain 5ebtC00

Image of CATH 5ebtD00

5ebtD00

CATH Domain 5ebtD00

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	11 Apr, 2016	Chopped
B	11 Apr, 2016	Chopped
C	11 Apr, 2016	Chopped
D	11 Apr, 2016	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5ebtA00	08 May, 2016	3.90.228.10	Assigned
5ebtB00	08 May, 2016	3.90.228.10	Assigned
5ebtC00	08 May, 2016	3.90.228.10	Assigned
5ebtD00	08 May, 2016	3.90.228.10	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
O95271	TNKS1_HUMAN	Homo sapiens	Poly [ADP-ribose] polymerase tankyrase-1
O95271	TNKS1_HUMAN	Homo sapiens	Poly [ADP-ribose] polymerase tankyrase-1
O95271	TNKS1_HUMAN	Homo sapiens	Poly [ADP-ribose] polymerase tankyrase-1
O95271	TNKS1_HUMAN	Homo sapiens	Poly [ADP-ribose] polymerase tankyrase-1