PDB 5cnj

PDB Information

PDB5CNJ
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist.
Monn, J.A., Prieto, L., Taboada, L., Hao, J., Reinhard, M.R., Henry, S.S., Beadle, C.D., Walton, L., Man, T., Rudyk, H., Clark, B., Tupper, D., Baker, S.R., Lamas, C., Montero, C., Marcos, A., Blanco, J., Bures, M., Clawson, D.K., Atwell, S., Lu, F., Wang, J., Russell, M., Heinz, B.A., Wang, X., Carter, J.H., Getman, B.G., Catlow, J.T., Swanson, S., Johnson, B.G., Shaw, D.B., McKinzie, D.L.
J.Med.Chem.
HeaderSignaling Protein
Released2015-07-17
Resolution2.650
CATH Insert Date20 Sep, 2015

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 21 Sep, 2015 Chopped
B 21 Sep, 2015 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
5cnjA01 30 Sep, 2015 3.40.50.2300 Assigned
5cnjA02 30 Sep, 2015 3.40.50.2300 Assigned
5cnjB01 30 Sep, 2015 3.40.50.2300 Assigned
5cnjB02 30 Sep, 2015 3.40.50.2300 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q14416 GRM2_HUMAN Homo sapiens Metabotropic glutamate receptor 2
Q14416 GRM2_HUMAN Homo sapiens Metabotropic glutamate receptor 2