PDB 5b4k

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Overview

PDB Information

PDB	5B4K
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli BL21(DE3)
Gene Source	Homo sapiens
Primary Citation	Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket Yoshikawa, M., Hitaka, T., Hasui, T., Fushimi, M., Kunitomo, J., Kokubo, H., Oki, H., Nakashima, K., Taniguchi, T. Bioorg.Med.Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2016-04-05
Resolution	2.900
CATH Insert Date	10 Jul, 2016

PDB Images (5)

Image of CATH 5b4k

5b4k

PDB 5b4k

Image of CATH 5b4kA

5b4kA

PDB Chain 5b4kA

Image of CATH 5b4kB

5b4kB

PDB Chain 5b4kB

Image of CATH 5b4kA00

5b4kA00

CATH Domain 5b4kA00

Image of CATH 5b4kB00

5b4kB00

CATH Domain 5b4kB00

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	11 Jul, 2016	Chopped
B	11 Jul, 2016	Chopped

CATH Domains (2)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5b4kA00	13 Jul, 2016	1.10.1300.10	Assigned
5b4kB00	13 Jul, 2016	1.10.1300.10	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
Q9Y233	PDE10_HUMAN	Homo sapiens	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Q9Y233	PDE10_HUMAN	Homo sapiens	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A