PDB 5b25

PDB Links
Overview

PDB Information

PDB	5B25
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli BL21(DE3)
Gene Source	Homo sapiens
Primary Citation	Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases Li, P., Zheng, H., Zhao, J., Zhang, L., Yao, W., Zhu, H., Beard, J.D., Ida, K., Lane, W., Snell, G., Sogabe, S., Heyser, C.J., Snyder, G.L., Hendrick, J.P., Vanover, K.E., Davis, R.E., Wennogle, L.P. J.Med.Chem.
Header	Hydrolase/Hydrolase Inhibitor
Released	2016-01-07
Resolution	1.900
CATH Insert Date	10 Apr, 2016

PDB Images (9)

Image of CATH 5b25

5b25

PDB 5b25

Image of CATH 5b25A

5b25A

PDB Chain 5b25A

Image of CATH 5b25B

5b25B

PDB Chain 5b25B

Image of CATH 5b25C

5b25C

PDB Chain 5b25C

Image of CATH 5b25D

5b25D

PDB Chain 5b25D

Image of CATH 5b25A00

5b25A00

CATH Domain 5b25A00

Image of CATH 5b25B00

5b25B00

CATH Domain 5b25B00

Image of CATH 5b25C00

5b25C00

CATH Domain 5b25C00

Image of CATH 5b25D00

5b25D00

CATH Domain 5b25D00

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	11 Apr, 2016	Chopped
B	11 Apr, 2016	Chopped
C	11 Apr, 2016	Chopped
D	11 Apr, 2016	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5b25A00	25 May, 2017	1.10.1300.10	Assigned
5b25B00	25 May, 2017	1.10.1300.10	Assigned
5b25C00	25 May, 2017	1.10.1300.10	Assigned
5b25D00	25 May, 2017	1.10.1300.10	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
Q01064	PDE1B_HUMAN	Homo sapiens	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Q01064	PDE1B_HUMAN	Homo sapiens	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Q01064	PDE1B_HUMAN	Homo sapiens	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Q01064	PDE1B_HUMAN	Homo sapiens	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B