PDB 4zgx

PDB Links
Overview

PDB Information

PDB	4ZGX
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys. Martin, R.E., Aebi, J.D., Hornsperger, B., Krebs, H.J., Kuhn, B., Kuglstatter, A., Alker, A.M., Marki, H.P., Muller, S., Burger, D., Ottaviani, G., Riboulet, W., Verry, P., Tan, X., Amrein, K., Mayweg, A.V. J.Med.Chem.
Header	Oxidoreductase
Released	2015-04-24
Resolution	3.200
CATH Insert Date	18 Oct, 2015

PDB Images (25)

4zgx

PDB 4zgx

4zgxA

PDB Chain 4zgxA

4zgxB

PDB Chain 4zgxB

4zgxC

PDB Chain 4zgxC

4zgxD

PDB Chain 4zgxD

4zgxE

PDB Chain 4zgxE

4zgxF

PDB Chain 4zgxF

4zgxG

PDB Chain 4zgxG

4zgxH

PDB Chain 4zgxH

4zgxI

PDB Chain 4zgxI

4zgxJ

PDB Chain 4zgxJ

4zgxK

PDB Chain 4zgxK

4zgxL

PDB Chain 4zgxL

4zgxA00

CATH Domain 4zgxA00

4zgxB00

CATH Domain 4zgxB00

4zgxC00

CATH Domain 4zgxC00

4zgxD00

CATH Domain 4zgxD00

4zgxE00

CATH Domain 4zgxE00

4zgxF00

CATH Domain 4zgxF00

4zgxG00

CATH Domain 4zgxG00

4zgxH00

CATH Domain 4zgxH00

4zgxI00

CATH Domain 4zgxI00

4zgxJ00

CATH Domain 4zgxJ00

4zgxK00

CATH Domain 4zgxK00

4zgxL00

CATH Domain 4zgxL00

PDB Prints

PDB Chains (12)

Chain ID	Date inserted into CATH	CATH Status
A	19 Oct, 2015	Chopped
B	19 Oct, 2015	Chopped
C	19 Oct, 2015	Chopped
D	19 Oct, 2015	Chopped
E	19 Oct, 2015	Chopped
F	19 Oct, 2015	Chopped
G	19 Oct, 2015	Chopped
H	19 Oct, 2015	Chopped
I	19 Oct, 2015	Chopped
J	19 Oct, 2015	Chopped
K	19 Oct, 2015	Chopped
L	19 Oct, 2015	Chopped

CATH Domains (12)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
4zgxA00	01 Nov, 2015	1.10.630.10	Assigned
4zgxB00	01 Nov, 2015	1.10.630.10	Assigned
4zgxC00	01 Nov, 2015	1.10.630.10	Assigned
4zgxD00	01 Nov, 2015	1.10.630.10	Assigned
4zgxE00	01 Nov, 2015	1.10.630.10	Assigned
4zgxF00	31 Oct, 2015	1.10.630.10	Assigned
4zgxG00	01 Nov, 2015	1.10.630.10	Assigned
4zgxH00	01 Nov, 2015	1.10.630.10	Assigned
4zgxI00	01 Nov, 2015	1.10.630.10	Assigned
4zgxJ00	01 Nov, 2015	1.10.630.10	Assigned
4zgxK00	01 Nov, 2015	1.10.630.10	Assigned
4zgxL00	01 Nov, 2015	1.10.630.10	Assigned

UniProtKB Entries (12)

Accession	Gene ID	Taxon	Description
P19099	C11B2_HUMAN	Homo sapiens	Cytochrome P450 11B2, mitochondrial
P19099	C11B2_HUMAN	Homo sapiens	Cytochrome P450 11B2, mitochondrial
P19099	C11B2_HUMAN	Homo sapiens	Cytochrome P450 11B2, mitochondrial
P19099	C11B2_HUMAN	Homo sapiens	Cytochrome P450 11B2, mitochondrial
P19099	C11B2_HUMAN	Homo sapiens	Cytochrome P450 11B2, mitochondrial
P19099	C11B2_HUMAN	Homo sapiens	Cytochrome P450 11B2, mitochondrial
P19099	C11B2_HUMAN	Homo sapiens	Cytochrome P450 11B2, mitochondrial
P19099	C11B2_HUMAN	Homo sapiens	Cytochrome P450 11B2, mitochondrial
P19099	C11B2_HUMAN	Homo sapiens	Cytochrome P450 11B2, mitochondrial
P19099	C11B2_HUMAN	Homo sapiens	Cytochrome P450 11B2, mitochondrial
P19099	C11B2_HUMAN	Homo sapiens	Cytochrome P450 11B2, mitochondrial
P19099	C11B2_HUMAN	Homo sapiens	Cytochrome P450 11B2, mitochondrial